Title

Effects of beta-Hydroxy-beta-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response

Authors

Authors

J. R. Townsend; J. R. Hoffman; A. Gonzalez; A. R. Jajtner; C. H. Boone; E. H. Robinson; G. T. Mangine; A. J. Wells; M. S. Fragala; D. H. Fukuda;J. R. Stout

Comments

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Abbreviated Journal Title

Int. J. Endocrinol.

Keywords

GROWTH-HORMONE RELEASE; COLD-WATER IMMERSION; SKELETAL-MUSCLE; AMINO-ACIDS; HMB SUPPLEMENTATION; PROTEIN-SYNTHESIS; PERFORMANCE; LEUCINE; DAMAGE; MEN; Endocrinology & Metabolism

Abstract

Objective. To examine the endocrine response to a bout of heavy resistance exercise following acute beta-hydroxy-beta-methylbutyrate free acid (HMB-FA) ingestion. Design. Twenty resistance trained men were randomized and consumed either 1 g of HMB-FA (BetaTor) or placebo (PL) 30 min prior to performing an acute heavy resistance exercise protocol. Blood was obtained before (PRE), immediately after (IP), and 30 min after exercise (30P). Circulating concentrations of testosterone, growth hormone (GH), insulin-like growth factor (IGF-1), and insulin were assayed. Data were analyzed with a repeated measures ANOVA and area under the curve (AUC) was analyzed by the trapezoidal rule. Results. The resistance exercise protocol resulted in significant elevations from PRE in testosterone (P < 0.01), GH (P < 0.01), and insulin (P = 0.05) at IP, with GH (P < 0.01) and insulin (P < 0.01) remaining elevated at 30P. A significant interaction was noted between groups in the plasma GH response at IP, which was significantly higher following HMB-FA compared to PL (P < 0.01). AUC analysis revealed an elevated GH and IGF-1 response in the HMB-FA group compared to PL. Conclusion. HMB-FA prior to resistance exercise augments the GH response to high volume resistance exercise compared to PL. These findings provide further support for the potential anabolic benefits associated with HMB supplementation.

Journal Title

International Journal of Endocrinology

Publication Date

1-1-2015

Document Type

Article

Language

English

First Page

7

WOS Identifier

WOS:000351071300001

ISSN

1687-8337

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