Authors

J. P. Rolland; P. Meemon; S. Murali; K. P. Thompson;K. S. Lee

Comments

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Abbreviated Journal Title

Opt. Express

Keywords

SPECTRAL-DOMAIN; LASER SOURCE; 1300 NM; TOMOGRAPHY; RESOLUTION; OCT; LENS; Optics

Abstract

We recently reported on an Optical Coherence Microscopy technique, whose innovation intrinsically builds on a recently reported - 2 mu m invariant lateral resolution by design throughout a 2 mm cubic full-field of view - liquid-lens-based dynamic focusing optical probe [Murali et al., Optics Letters 34, 145-147, 2009]. We shall report in this paper on the image acquisition enabled by this optical probe when combined with an automatic data fusion method developed and described here to produce an in-focus high resolution image throughout the imaging depth of the sample. An African frog tadpole (Xenopus laevis) was imaged with the novel probe and the Gabor-based fusion technique, demonstrating subcellular resolution in a 0.5 mm (lateral) x 0.5 mm (axial) without the need, for the first time, for x-y translation stages, depth scanning, high-cost adaptive optics, or manual intervention. In vivo images of human skin are also presented.

Journal Title

Optics Express

Volume

18

Issue/Number

4

Publication Date

1-1-2010

Document Type

Article

Language

English

First Page

3632

Last Page

3642

WOS Identifier

WOS:000274795700045

ISSN

1094-4087

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