Nanobioimaging and sensing of infectious diseases
Abbreviated Journal Title
Adv. Drug Deliv. Rev.
Fluorescent nanoparticles; Multiplexing; Viral imaging; Bacterial; detection; Surface plasmon resonance; Colorimetric assay; Magnetic; nanosensors; Immunomagnetic separation; BIOFUNCTIONAL MAGNETIC NANOPARTICLES; SYNCYTIAL VIRUS-INFECTION; ESCHERICHIA-COLI O157/H7; GRAM-NEGATIVE BACTERIA; QUANTUM-DOT PROBES; IMMUNOMAGNETIC SEPARATION; SILICA NANOPARTICLES; GOLD NANOPARTICLES; PATHOGEN DETECTION; RAPID DETECTION; Pharmacology & Pharmacy
New methods to identify trace amount of infectious pathogens rapidly, accurately and with high sensitivity are in constant demand to prevent epidemics and loss of lives. Early detection of these pathogens to prevent, treat and contain the spread of infections is crucial. Therefore, there is a need and urgency for sensitive, specific, accurate, easy-to-use diagnostic tests. Versatile biofunctionalized engineered nanomaterials are proving to be promising in meeting these needs in diagnosing the pathogens in food, blood and clinical samples. The unique optical and magnetic properties of the nanoscale materials have been put to use for the diagnostics. In this review, we focus on the developments of the fluorescent nanoparticles, metallic nanostructures and superparamagnetic nanoparticles for bioimaging and detection of infectious microorganisms. The various nanodiagnostic assays developed to image, detect and capture infectious virus and bacteria in solutions, food or biological samples in vitro and in vivo are presented and their relevance to developing countries is discussed. (C) 2009 Elsevier B.V. All rights reserved.
Advanced Drug Delivery Reviews
"Nanobioimaging and sensing of infectious diseases" (2010). Faculty Bibliography 2010s. 857.