A review of pharmacological and psychosocial management of AIDS dementia complex

Abstract

AIDS Dementia Complex (ADC) is a common neurological complication of HIV/AIDS. ADC is characterized by cognitive, behavioral, and motor impairments including slowed thinking, decreased concentration, forgetfulness, apathy, irritability, anxiety, clumsiness, leg weakness, and altered handwriting. Symptoms progress into pronounced verbal and motor slowing, extensive thought disturbances, profound disorientation, hostility, ataxia, incontinence, and eventually a near vegetative state. Presently, no cure is available for ADC. However, treatment with the antiretroviral drug, zidovudine (AZT), has been shown to slow the progression of ADC and improve functioning. Other promising pharmacological treatments under investigation include newer antiretroviral drugs, combination use of protease inhibitors and zidovudine, calcium channel blocking agents, receptor antagonists for excitatory neurotransmitters, and antagonists of cytokines and inflammatory agents. Psychosocial interventions for managing patients in the early stages of ADC focus on preserving independence, promoting self-esteem, and assisting patients to compensate for cognitive changes. During the later stages of ADC, interventions deal with adapting patients' environments to ensure safety and maintain structure, routine, and simplicity. Prompt intervention is essential to improving the quality and length of these patients' lives.

Notes

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Thesis Completion

1999

Semester

Spring

Advisor

Giovinco, Gina

Degree

Bachelor of Science in Nursing (B.S.N.)

College

College of Health and Public Affairs

Degree Program

Nursing

Subjects

Dissertations, Academic -- Health and Public Affairs;Health and Public Affairs -- Dissertations, Academic

Format

Print

Identifier

DP0021576

Language

English

Access Status

Open Access

Length of Campus-only Access

None

Document Type

Honors in the Major Thesis

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