A collection of Medicine Masters Theses and Doctoral Dissertations.

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Theses/Dissertations from 2017

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Characterization of Novel Borrelia burgdorferi Transcripts Expressed during Tick and Mammalian Infection, Philip Adams

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A Major DNA Double Strand Repair Pathway and Cancer-Associated Circulating Proteins are Effecters of Epigenetic Revision., Brittany Allen

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Implication of Alpha-synuclein Transcriptional Regulation and Mutagenesis in the Pathogenesis of Sporadic Parkinson's Disease, Sambuddha Basu

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Plasticity of Central and Peripheral Nervous System: Effects of Oxygen-Glucose Deprivation (OGD) and Chronic Intermittent Hypoxia (CIH), Jin Chen

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Discovery and Characterization of Antimalarials with Novel Mechanisms of Action, Bracken Roberts

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The Actin-Severing Protein Cofilin Is Downstream Of Neuregulin Signaling, Is Regulated By The Tumor Suppressor Merlin, And Is Essential For Schwann Cell Myelination, Nicklaus Sparrow

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Cathepsin B Regulates VLDL Secretion Through LFABP Cleavage, Simeon Thibeaux

Theses/Dissertations from 2016

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Could Dietary Peroxidized Lipids provoke an Intestinal Inflammatory Response?, Mitsushita Doomra

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The mauC gene encodes a versatile signal sequence and redox protein that can be utilized in native and non-native protein expression and electron trnasfer systems, Brian Dow

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Apolipoprotein-AI Regulates Hepatic VLDL Secretion by Controlling Intracellular VLDL-Trafficking, Bhavesh Gurwani

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VO-OHpic Treatment Reduces Cardiac Remodeling in Doxorubicin-Induced Cardiomyopathy, Taylor Johnson

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The Role of SOD1 Acetylation in Neurodegeneration, Michael Kaliszewski

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The Role of Type-I Interferon in Limiting Spread and Killing of an Oncolytic RNA Virus in Prostate Cells, Kritika Kedarinath

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Role of Kruppel-like Factor 8 (KLF8) in Cancer and Cardiomyopathy, Satadru Lahiri

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Neurological profile of older ApoE-PON1 double knockout mice, Connie Mitra

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Role of KLF8-CXCR4 signaling in Breast Cancer Metastasis, Debarati Mukherjee

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Involvement of miRNAs in the Development of Androgen Independent Prostate Cancer, Richard Ottman

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Chlamydia trachomatis Transformants Show a Significant Reduction in Rates of Invasion upon Removal of Key Tarp Domains, Christopher Parrett

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Malondialdehyde (MDA) and Glutathione Peroxidase (GPx) are Elevated in Crohns Disease-Associated with Mycobacterium Avium Subspecies Paratuberculosis (MAP), Ahmad Qasem

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Structural and functional characterization of enzymes of a novel group of tryptophylquinone cofactor containing oxidases, Esha Sehanobish

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BMP-7 Inhibits p38 and JNK Pathways and Increases M2 Macrophage Differentiation to Reduce Atherosclerosis in Apolipoprotein E-/- Mice, Heidi Shoulders

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The development of motuporamine derivatives and an investigation into their biological properties, Kristen Skruber

Theses/Dissertations from 2015

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TIMP-1 Activates a Unique Cardiac Stem Cell Population, CD63+ve/C-KIT+ve, Thereby Enhancing Cardiac Differentiation, and Protects the Heart From Adverse Cardiac Remodeling Following Myocardial Infarction, Latifa Abdelli

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Differential Expression Of Proteins Involved In VLDL Trafficking Causes Reduced VLDL Secretion In Male Ames Dwarf Mice, Faisal Ahmed Moinuddin

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Diabetes Phenotypes in Transgenic Pancreatic Cancer Mouse Models, Toya Albury-Warren

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Evaluation of Intestinal Microbial Diversity and a New Antibiotic Regimen in Crohn's Disease Patients, Karel Alcedo

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The CT20 peptide as an agent for cancer treatment, Rania Bassiouni

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Synthesis and Characterization of Antimicrobial Non-Color Forming Silica-Silver Nanocomposite, Joshua Bazata

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Synthesis and Characterization of Core-Shell Zinc Silica Nanoparticles and Zinc Silica Nanogels for Agricultural Applications., Megan Berroth

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FMF assay for assessing vaccine generated antibodies in a biomimetic manner, Vipra Dhir

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Membrane topology of a broad-spectrum resistance factor responsible for lipid modification in Enterococcus faecium., Jesse Harrison

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Overexpression of human Cu/Zn Superoxide Dismutase in Mice; The Effect of Increase Superoxide Scavenging on Autonomic Control of the Heart., Jeffrey Hatcher

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Functional Identification of Nucleus Tractus Solitarius (NTS) Barosensitive Neurons: Effect of Chronic Intermittent Hypoxia (CIH), Jenya Kolpakova

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The role of a highly conserved eubacterial ribosomal protein in translation quality control, Anusha Naganathan

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Genetically-programmed suicide of adrenergic cells in the mouse leads to severe left ventricular dysfunction, impaired weight gain, and symptoms of neurological dysfunction, Aaron Owji

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Development of Cytotoxic Natural Killer Cells for Ovarian Cancer Treatment, Veethika Pandey

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Proteomic Analysis Delineates the Signaling Networks of Plasmodium falciparum, Brittany Pease

Theses/Dissertations from 2014

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Preparation, Characterization, and Delivery of Antibodies Binding to a Model Oncogenic RNA, Human Initiator tRNA, Jennifer Archer

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Role of Cardiac Catecholamines in Embryos and Adults Under Stress, Candice Baker

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Modulation of cholera toxin structure and function by host proteins, Helen Burress

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The Anti-toxin Properties of Grape Seed Phenolic Compounds, Patrick Cherubin

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Amyotrophic Lateral Sclerosis: mechanism behind mutant SOD toxicity and improving current therapeutic strategies, Cassandra Dennys

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Cerium oxide Nanoparticles: Their Phosphatase Activity and its Control, Atul Dhall

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Genetic and biochemical characterization of the roles of two putative purine transporters in the infectious cycle of Borrelia burgdorferi, Sunny Jain

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In Vitro Characterization of Unmodified and Pyroglutamylated Alzheimer's Amyloid beta peptide, Jason Matos

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Host and Bacterial Determinants of Staphylococcus aureus Nasal Colonization in Humans, Gowrishankar Muthukrishnan

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Purification and Characterization of a Novel Selenocysteine Lyase from Enterococcus faecalis, Samantha Nelson

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The Role of LIM Kinase 1 and its Substrates in Cell Cycle Progression, Lisa Ritchey

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Validation Of A Novel Hypothesis Of Generating Foam Cells By Its Use To Study Reverse Cholesterol Transport, Bhaswati Sengupta

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Establishment of Methods for Isolation of Pnmt+ Cardiac Progenitor Cells, Namita Varudkar

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Antimicrobial Peptide Resistance and Immunomodulation by HIV-1 gp41, Matthew Wood

Theses/Dissertations from 2013

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The Role Of Mitochondrial Omi/htra2 Protease In Protein Quality Control And Mitophagy, Camilla Ambivero

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The Cytopathic Activity Of Cholera Toxin Requires A Threshold Quantity Of Cytosolic Toxin., Carly Bader

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Delineating Key Genetic Components On Linear Plasmid 36 That Contribute To Its Essential Role In Borrelia Burgdorferi Mammalian Infectivity., Tisha Choudhury

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Characterization Of Innate Immunity In The Female Reproductive Tract For The Prevention Of Hiv Acquisition, Colleen Eade

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Target Validation For Neurofibromatosis Type 2 Therapeutics., Alejandra Guinart

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Is Breakdown Of Fatty Acid Peroxides Involved In The Induction Of Apolipoprotein A1?, Rajat Gupta

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Immuno-pcr Detection Of Lyme Borreliosis, Micah Halpern

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Identification Of Epithelial Stromal Interaction 1 And Epidermal Growth Factor Receptor As Novel Kruppel-like Factor 8 Targets In Promoting Breast Cancer Progression, Tianshu Li

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The Contribution Of Visceral Fat To Positive Insulin Signaling In Ames Dwarf Mice, Vinal Menon

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Characterization Of Motility Alterations Caused By The Impairment Of Dynein/dynactin Motor Protein Complex, Swaran Nandini

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Role Of Host Immune Response And Bacterial Autolysin Atl In Human Nasal Colonization By Staphylococcus Aureus, Vanathy Paramanandam

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Molecular Regulators Of Post-golgi Vldl Transport Vesicle (pg-vtv) Biogenesis, Aladdin Riad

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Bone Morphogenetic Protein-7 (bmp-7) Polarizes Monocytes Into M2 Macrophages, Crystal Rocher

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Screening Of Quantum Dots For Toxicity On The Growth And Viability Of Escherichia Coli, Jeremy Tharkur

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Identification Of Proteins Regulating Vldl Sorting Into The Vldl Transport Vesicle (vtv) And Involved In The Biogenesis Of The Vtv, Samata Tiwari

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Bone Morphogenetic Protein-7 Attenuates Inflammation And Apoptosis And Improves Cardiac Function In Diabetes, Princess Urbina

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Cholera Toxin Activates The Unfolded Protein Response Through An Adenylate Cyclase-independent Mechanism, Neyda VanBennekom

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Cerium Oxide Nanoparticles Sensitize Pancreatic Cancer Cells To Radiation By Promoting Acidic Ph, Ros, And Jnk Dependent Apoptosis, Melissa Wason

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Mixed Valence Copper(cu)/silica Nanocomposite: Synthesis, Characterization And Systematic Antimicrobial Studies, Mikaeel Young

Theses/Dissertations from 2012

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The Dynamic Functions Of Bax Are Dependent On Key Structural And Regulatory Features, Rebecca Boohaker

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Light-activated Binary Nucleotide Reagent For Inactivation Of Dna Polymerase, Evan M. Cornett

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Cerium Oxide Nanoparticles Act As A Unique Catalyst And Scavenge Nitric Oxide And Peroxynitrite And Decrease Rns In Vitro And In Vivo, Janet Dowding

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Manipulation Of Host Signal Transduction Pathways And Cytoskeleton Functions By Invasive Bacterium Listeria Monocytogenes And Chlamydia Trachomatis, Shahanawaz Jiwani

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Amelioration Of Amyloid Burden In Advanced Human And Mouse Alzheimer's Disease Brains By Oral Delivery Of Myelin Basic Protein Bioencapsulated In Plant Cells, Neha Kohli

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Expression Of Lipase From Mycobacterium Tuberculosis In Nicotiana Tobacum And Lactuca Sativa Chloroplasts, Bethany Lloyd

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Transplantation Of Pluripotent Stem Cells Confers Cardiac Protection In Dox-induced Heart Failure Through Notch-1 Pathway, Hilda Merino-Chavez

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Limk1 Promotes Mt1-mmp Expression And Localization To The Plasma Membrane, Richard Ottman

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Identification Of Novel Antimalarial Scaffolds From Marine Natural Products, Bracken Roberts

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Molecular Mechanisms Involved In Inflammatory Angiogenesis Induced By Monocyte Chemotactic Protein Induced Protein-1 (mcpip1), Arpita Roy

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Signals Delivered By Interleukin-7 Regulate The Activities Of Bim And Jund In T Lymphocytes, Shannon Moore Ruppert

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Novel Immunogens Of Cellular Immunity Revealed Using In Vitro Human Cell-based Approach, Brian Schanen

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A Novel Link Between Akt1 And Twist1 In Ovarian Tumor Cell Motility And Invasiveness, Nirav Shah

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Defective Dynamics Of Mitochondria In Amyotrophic Lateral Sclerosis And Huntington's Disease, Wenjun Song

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Dubious Role Of Mycobacterium Paratuberculosis In Pathogenesis Of Type I Diabetes, Saisathya Thanigachalam

Theses/Dissertations from 2011

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Expression Of Trichoderma Reesei Beta]-mannanase In Tobacco Chloroplasts And Its Utilization In Lignocellulosic Woody Biomass Hydrolysis, Pankaj M. Agrawal

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Mechanisms Of Alpha]-synuclein-induced Neurodegenertaion In Parkinson's Disease And Stroke, Cherine Belal

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A Solid Phase Assay For Topoisomerase I Interfacial Poisons And Catalytic Inhibitors, Vidusha Cyril

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Glial Differentiation Of Human Umbilical Stem Cells In 2d And 3d Environments, Hedvika Davis

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Stable Expression Of Tuberculosis Vaccine Antigen In Lettuce Chloroplasts, Priya Saikumar Lakshmi

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Evolutionary Relationships Among Staphylococci And The Prevention Of Staphylococcus Aureus Nasal Colonization, Ryan Paul Lamers

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Novel Copper Loaded Core-shell Silica Nanoparticles With Improved Copper Bioavailability Synthesis, Characterization And Study Of Antibacterial Properties, Pavithra Maniprasad

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Synthesis, Characterization And Antibacterial Activity Of Silver Embedded Silica Nanoparticle/nanogel Formulation, Roseline Menezes

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Expression And Functional Evaluation Of Exendin 4 Fused To Cholera Toxin B Subunit In Tobacco Chloroplast To Treat Type 2 Diabetes, Ramya Nityanandam

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Development Of Molecular And Cellular Imaging Tools To Evaluate Gene And Cell Based Therapeutic Strategies In Vivo, Jixiang Xia

Theses/Dissertations from 2010

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Identification Of Novel Antimalarials From Marine Natural Products For Lead Discovery, Stephenie M. Alvarado

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Acetazolamide-induced Decrease Of Apical Fluid Flow In Choroid Plexus Is Independent Of The Concomitant Changes In Aquaporin-1 Expression, Pouya Alexander Ameli

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Studies On A Novel Human Cardiospecific Transcription Factor And Its Involvement In Omi/htra2 Mediated Cell Death, Meenakshi Puthucode Balakrishnan

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Low Cost Production Of Proinsulin In Tobacco And Lettuce Chloroplasts For Injectable Or Oral Delivery Of Functional Insulin And, Diane Burberry

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The Cytokine, Interleukin-7, Transcriptionally Regulates The Gene Expression Of The Hexokinase Ii To Mediate Glucose Utilization, Mounir Chehtane