Abstract

Polyamines are important cellular growth factors and are involved in inflammation. Both spermidine and N1-acetylspermine were identified as statistically elevated in inflammatory bowel tissue samples. Moreover, spermidine levels were also elevated in circulating mono nuclear cells of IBD patients compared to healthy controls. This observation provides the opportunity to develop an assay, which measures these polyamine markers in patient blood, patient bodily fluids, feces and/or in tissue biopsies obtained from patients. This patent claims the concept of measuring these specific markers and their use as diagnostic tools for monitoring and diagnosing disease processes such as inflammatory bowel disease and cancer.

Document Type

Patent

Patent Number

US 7,972,807

Application Serial Number

12/139,710

Issue Date

7-5-2011

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

College of Sciences

Department

Chemistry

Allowance Date

2-28-2011

Filing Date

6-16-2008

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

Download Patent

Share

COinS