Abstract

Cyano-substituted anthracene containing polyamines were synthesized and shown to be efficient polyamine transporter ligands. Moreover, these agents (3 and 4) had improved fluorescence properties over previous anthryl-polyamine conjugates, which facilitated their intracellular trafficking by confocal microscopy. These cytotoxic fluorescent agents may find use as molecular probes which traffick into cells via the polyamine transport system and may also be viable anticancer drugs which are readily quantified in human tissues due to their excellent fluorescence properties: (excitation: ? 405 nm) and emission (420 nm) occurs in the visible light range. The ability to excite and emit in the visible range provides an advantage to these probes as these wavelengths are not toxic to human cells (versus ultraviolet mediated excitations, ?<400 >nm) and visible light lasers are less costly to purchase and operate than UV laser sources.

Document Type

Patent

Patent Number

US 8,410,311

Application Serial Number

12/754,962

Issue Date

4-2-2013

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

College of Sciences

Department

Chemistry

Allowance Date

11-29-2012

Filing Date

4-6-2010

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

Download Patent

Share

COinS