Cyano-substituted anthracene containing polyamines were synthesized and shown to be efficient polyamine transporter ligands. Moreover, these agents (3 and 4) had improved fluorescence properties over previous anthryl-polyamine conjugates, which facilitated their intracellular trafficking by confocal microscopy. These cytotoxic fluorescent agents may find use as molecular probes which traffick into cells via the polyamine transport system and may also be viable anticancer drugs which are readily quantified in human tissues due to their excellent fluorescence properties: (excitation: ? 405 nm) and emission (420 nm) occurs in the visible light range. The ability to excite and emit in the visible range provides an advantage to these probes as these wavelengths are not toxic to human cells (versus ultraviolet mediated excitations, ?<400 >nm) and visible light lasers are less costly to purchase and operate than UV laser sources.
Application Serial Number
Assignee at Issuance
College of Sciences
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Nonprovisional Application Record
Phanstiel, Otto, "Fluorescent cytotoxic compounds specific for the cellular polyamine transport system" (2013). UCF Patents. 194.