Abstract

Disclosed herein are compounds derived from a chemical structure according to the formula (I) wherein X comprises oxygen or sulfur, R1 comprises a phenyl or naphthyl group, R2 comprises an amide group and R3 comprises a phosphate group. The disclosed compounds demonstrate inhibitory activity against STAT3, a protein found in certain tumor tissues and which promotes cellular overproliferation and resistance to apoptosis. The invention includes compositions containing the disclosed compounds, as well as methods of treatment therewith.

Document Type

Patent

Patent Number

US 8,969,578

Application Serial Number

13/119,575

Issue Date

3-3-2015

Current Assignee

Joint Assignment w/UCFRF: Yale University

Assignee at Issuance

Joint Assignment w/UCFRF: Yale University

College

Burnett School of Biomedical Sciences

Department

Biomolecular Science Center

Allowance Date

10-7-2014

Filing Date

3-17-2011

Assignee at Filing

Joint Assignment w/UCFRF: Yale University

Filing Type

National Filing Record

Donated

no

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