A method of decreasing the expression of LIM kinase 1 in a cancer cell comprising; providing an oligonucleotide consisting of the sequence of SEQ ID NO: 1; providing a cancer cell comprising an mRNA encoding LIM kinase 1; and introducing the oligonucleotide into the cancer cell, wherein the oligonucleotide decreases the expression of LIM kinase 1 in the cancer cell. The method also provides compositions of an antisense RNA LIM kinase 1 that can be administered to an individual for the purpose of inhibiting a protein kinase pathway and which further comprises methods for treating and monitoring the proliferation and metastasis of cancer cells. A kit may be used in the detection and treatment of cancer.
US 8,802,649 B2
Application Serial Number
Assignee at Issuance
Burnett School of Biomedical Sciences
Biomolecular Science Center
Assignee at Filing
Nonprovisional Application Record
Chakrabarti, Ratna, "Methods and compositions for inhibiting the proliferation of cancer cells (DIV)" (2014). UCF Patents. 365.