A novel class of methyl esters of substituted 4-oxo-2-butenoic acids and their derivatives are disclosed along with the surprising use property of these compounds as a bacteriostatic agents for humans or non-humans against mycobacteria. These compounds include: 4-(4-Ethoxy-phenyl)-2-(N-fluoren-9-ylidene-hydrazino)-4-oxo-but-2-enoic acid methyl ester; 4-(4-Ethoxy-phenyl)-2-(N-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-but yric acid methyl ester; 2-(4-Bromo-phenylamino)-5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester; A pharmaceutical composition is disclosed as well as the method of treating human and non-humans infected with M. tuberculosis and related mycobacteria.
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College of Sciences
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Nonprovisional Application Record
Miles, Delbert; Goun, Elena; Michailovich, Suslonov; Michailovich, Suslonov; Naser, Saleh; Pertrovna, Krasnych; and Yurjevich, Solodnikov, "Methyl esters of substituted 4-OXO-2-butenoic acids for treatment of tuberculosis" (2004). UCF Patents. 380.