Abstract

Disclosed are nanoparticles having a metallic core consisting essentially of superparamagnetic iron oxide: a polymeric coat surrounding said core, the coat having a matrix of polyacrylic acid and forming an outer periphery of said nanoparticle; a pleurality of hydrophobic pockets formed by the polymeric coat; a plurality of carboxylic groups along an outer periphery of the polymeric coat and effective to conjugate with a predeterminded targeting ligand which functionalizes the nanoparticle; a lipophylic fluorescent dye encapsulated in the pleurality of hydrophobix pockets. Associated methods of making the nanoparticles and of treatments using the nanoparticles are also disclosed.

Document Type

Patent

Patent Number

US 8,236,284 B1

Application Serial Number

12/416,993

Issue Date

8-7-2012

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

NanoScience Technology Center

Department

NanoScience Technology Center

Allowance Date

4-2-2012

Filing Date

4-2-2009

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

Download Patent

Share

COinS