Abstract

Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.

Document Type

Patent

Patent Number

US 8,497,398

Application Serial Number

12/113,540

Issue Date

7-30-2013

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

College of Sciences

Department

Chemistry

Allowance Date

3-27-2013

Filing Date

5-1-2008

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

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