Abstract
Methods, systems and compositions are disclosed wherein normal, nontransformed, healthy biological cells are protected from oxidative stress, radiation therapy and chemotherapy while diseased, transformed cells, such as, cancer cells, are provided no protection by the biocompatible, polymer coated nanoceria composition of the present invention. The polymer-coated nanoceria preparation herein exhibits no toxicity to normal cells and exhibits pH-dependent antioxidant properties at neutral or physiological pH values, between approximately 6.5 to approximately 1 1.0 and is inactive as an antioxidant at acidic pH values between approximately 2.0 to approximately 6.4. Improved therapeutic agents and cytoprotecting devices are based on the newly discovered, pH dependent properties of polymer-coated nanoceria that provide selective cytoprotection.
Document Type
Patent
Patent Number
US 9,119,391 B1
Application Serial Number
12/169,179
Issue Date
9-1-2015
Current Assignee
UCFRF
Assignee at Issuance
UCFRF
College
NanoScience Technology Center
Department
NanoScience Technology Center
Allowance Date
4-23-2015
Filing Date
7-8-2008
Assignee at Filing
UCFRF
Filing Type
Nonprovisional Application Record
Donated
no
Recommended Citation
Perez Figueroa, J. Manuel; Asati, Atul; Kaittanis, Charalambos; and Nath, Sudip, "Polymer Coated Ceria Nanoparticles for Selective Cytoprotection (CIP)" (2015). UCF Patents. 468.
https://stars.library.ucf.edu/patents/468