Abstract
The molecular chaperone Hsp90 binds specifically to hTERT and is required for assembly of active telomerase activity. We show that disruption of Hsp90 function gy geldanamycin efficient ubiquitination and proteasome-mediated degradation of hTERT.
Document Type
Patent
Patent Number
US 7,901,906
Application Serial Number
11/279,151
Issue Date
3-8-2011
Current Assignee
UCFRF
Assignee at Issuance
UCFRF
College
Burnett School of Biomedical Sciences
Department
Molecular Biology & Microbiology
Allowance Date
10-22-2010
Filing Date
4-10-2006
Assignee at Filing
UCFRF
Filing Type
Nonprovisional Application Record
Donated
no
Recommended Citation
Muller, Mark; Chung, In; Kang, Mi; Kim, Jun; Lee, Tae; Oh, Sue; and Park, Sun, "Targeting of MKRNI for identifying cancer treatment agents" (2011). UCF Patents. 586.
https://stars.library.ucf.edu/patents/586
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