Abstract

The dynamics of intracellular pH is believed to be crucial for understanding the regulation mechanism of many physiological functions. Of the several methods avaible to detmermine pH, optical methods have several advantages including rapid response time, high signal-to-noise ratio, noninvasive, and excellent pH sensitivity. Since the first use of trapped intracellular pH probe, 6-carboxyfluorecein, was described by Thomas et al., a large number of pH indicators have been reported. SEE DISCLOSURE

Document Type

Patent

Patent Number

US 8,759,381 B1

Application Serial Number

13/546,248

Issue Date

6-24-2014

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

College of Sciences

Department

Chemistry

Allowance Date

8-30-2013

Filing Date

7-11-2012

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

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