Abstract

The present invention provides methods for reducing, reversing or inhibiting neovascularization of a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing, or inhibiting neovascularization in ocular tissue such as the retina, macula, or the cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing, or inhibiting angiogenesis in a mammalian subject.

Document Type

Patent

Patent Number

US 8,703,200 B2

Application Serial Number

12/429,650

Issue Date

4-22-2014

Current Assignee

Joint Assignment w/UCFRF: University of Oklahoma

Assignee at Issuance

Joint Assignment w/UCFRF: University of Oklahoma

College

Advanced Materials Processing & Analysis Center (AMPAC)

Department

Advanced Materials Processing & Analysis Center (AMPAC)

Filing Date

4-24-2009

Assignee at Filing

Joint Assignment w/UCFRF: University of Oklahoma

Filing Type

Nonprovisional Application Record

Donated

no

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