Abstract

Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.

Document Type

Patent

Patent Number

US 7,347,987 B2

Application Serial Number

11/796,347

Issue Date

3-25-2008

Current Assignee

Joint Assignment w/UCFRF: University of Oklahoma

Assignee at Issuance

Joint Assignment w/UCFRF: University of Oklahoma

College

Advanced Materials Processing & Analysis Center (AMPAC)

Department

Advanced Materials Processing & Analysis Center (AMPAC)

Allowance Date

12-17-2007

Filing Date

4-27-2007

Assignee at Filing

Joint Assignment w/UCFRF: University of Oklahoma

Filing Type

Nonprovisional Application Record

Donated

no

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