oxygen deprived never cells produce high levels of glutanate which stimulates the NMDA receptor know to cause cell death the ucf anthracene-polyamine derivative blocks NMDA receptor very efficiently with an IC50 (65nm) whereas a current drug now used in alzheimer treatments has an IC50 (460nm) our compound is therefore 7 times more potent and could lead to a new therapy for human diseases which involve the ndma receptor
US 7,728,040 B1
Application Serial Number
Assignee at Issuance
College of Sciences
Assignee at Filing
Nonprovisional Application Record
Phanstiel, Otto, "Polyamine conjugates as selective NMDA inhibitors and anti-cancer drugs" (2010). UCF Patents. 777.