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Theses/Dissertations from 2019

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AB Toxins: Recovery from Intoxication and Relative Potencies, Patrick Cherubin

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Alpha-Tocopherol Reduces VLDL Secretion Through Modulation of the VLDL Transport Vesicle, Ryan Clay

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Development of a Functional Testing Platform for the Sensory Segment of the Neuromuscular Reflex Arc, Alisha Colon

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A Cytoplasmic-Replicating RNA Virus Sensitizes Cancer Cells to DNA Modifying Agents, Candace Fox

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Bone Morphogenetic Protein 7 Inhibits Pyroptotic Cell Death in Vascular Smooth Muscle Cells of Atherosclerotic Apolipoprotein E -/- Mice, Kaley Garner

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Multi-target High-throughput Screening Assays for Antimicrobial Drug Discovery, Christopher Grube

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Unraveling PDI and its Interaction with AB Toxins, Jessica Guyette

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Identification and Functional Characterization of a Long Non-coding RNA associated with Prostate Cancer, Md Faqrul Hasan

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ATP Induced Molecular Disassembly of Cytolethal Distending Toxin's B/C Heterodimer, George Huhn

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Synthesis and Bioevaluation of Methionine Depletion Agents, Houssine Ikhlef

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Phenotypic and Molecular Characterization of the Emergent Marine Pathogen Vibrio vulnificus, Jane Maureen Jayakumar

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Selenium vs. Sulfur: Investigating the Substrate Specificity of a Selenocysteine Lyase, Michael Johnstone

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It Takes Two to Tango: The Toxin-chaperone Relationship, Alisha Kellner

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Use of Artificial Intelligence for Malaria Drug Discovery, Arash Keshavarzi Arshadi

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Zika Virus-induced Lysis of Cervical Cancer Cells, Harini Krishnapura

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Unraveling the Role of Phenylethanolamine N-methyltransferase (Pnmt+) Cells In-vivo, Sanjana Manja

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Motor and Sensory Characterization of a Mouse Model of Charcot-Marie-Tooth Type 2O Disease, Swaran Nandini

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Role of TNFα Antagonists and Genetic Polymorphisms in Modulating Susceptibility to Mycobacterial Infection among Patients with Crohn's Disease, Ahmad Qasem

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Allelic Characterization and Novel Functions of the Outer Membrane Porin U in Vibrio Cholerae, Sk Nazmus Sakib

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Metabolic Effects of 17a-Estradiol are Growth Hormone Independent and Sex Specific, Silvana Sidhom

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Determining Differential Effects of Interleukin-2 on Innate and Adaptive Immune Cells in Lymphoid Organs and the Gastrointestinal Tract, Ayushi Singh

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Mechanism of NANOGP8 in Glioblastoma Multiforme, Jonhoi Smith

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Biochemical Characterization of Rv2633c from Mycobacterium tuberculosis and the Effects of Mutagenesis on Iron Binding, Kyle Strickland

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Investigating Changes in Quiescence in Oral and Esophageal Epithelium in Response to Injury, Alexandra Troia

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Strategies for Improving Efficacy of Metal and Non-metal Based Antimicrobial Agents, Mikaeel Young

Theses/Dissertations from 2018

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Development of a Functional In Vitro 3D Model of the Peripheral Nerve, Wesley Anderson

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Regulation of Extra-Pituitary Prolactin in Monocytes and Macrophages, Richard Barrett

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Knowledge and Attitudes Regarding the Recent Zika Outbreak Among a Sample of South Florida Residents, Mohamed Elakkari

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Dissecting the Components of Neuropathic Pain, Dale George

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Embryonic Stem Cell Derived Exosomes Enhance Cardiac Stem Cell Differentiation into Heart Cells, Jamillah Hammond

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Role of Mycobacterium avium paratuberculosis (MAP) and TNFSF15 SNPs on TL1A in CD, Sayf Al-Deen Hassouneh

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Development of a Non-Human Primate Model for Staphylococcus aureus Nasal Carriage, Amanda Lasseter

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Deciphering the Role of Adrenergic Hormones in Embryonic Cardiac Calcium Signaling and Metabolism, Jessica Peoples

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Role of Lipid Peroxide Derived Dicarboxylic Acids in Atherosclerotic Calcification, Aladdin Riad

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Characterization of Neural Cells Derived from Reelin-deficient Schizophrenic Patient iPS Cells, Nicole Roberts

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Neuromuscular Junction Defects in a Mouse Model of Charcot-Marie-Tooth Disease Type 2O, Thywill Sabblah

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PG-VTV Biogenesis Requires ATP to Facilitate Phosphorylation of Syntaxin 17, Anika Saxena

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Role of Single Nucleotide Polymorphisms (SNPs) in PTPN2/22 and Mycobacterium Avium Subspecies Paratuberculosis (MAP) in Rheumatoid Arthritis and Crohn's Disease, Robert Sharp

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Embryonic Stem Cell-Derived Exosomes Inhibit Doxorubicin-Induced Pyroptosis in Cell Culture Models, Zahra Tavakoli Dargani

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Exacerbation of ΔEFP Sickness in Escherichia coli By an Uncharacterized RNA Helicase, Robert Wingo

Theses/Dissertations from 2017

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Characterization of Novel Borrelia burgdorferi Transcripts Expressed during Tick and Mammalian Infection, Philip Adams

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A Major DNA Double Strand Repair Pathway and Cancer-Associated Circulating Proteins are Effecters of Epigenetic Revision., Brittany Allen

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Implication of Alpha-synuclein Transcriptional Regulation and Mutagenesis in the Pathogenesis of Sporadic Parkinson's Disease, Sambuddha Basu

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Development of Molecular Diagnostic Tools for Mycobacterium Species, Hillary Bengtson

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Chaperonin Containing TCP1 (CCT) as a Target for Cancer Therapy, Ana Carr

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Plasticity of Central and Peripheral Nervous System: Effects of Oxygen-Glucose Deprivation (OGD) and Chronic Intermittent Hypoxia (CIH), Jin Chen

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Targeted Therapy Development for Neurofibromatosis Type 2, Marisa Fuse

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Novel Cytokine Signaling and Molecular Therapeutic Strategy in Pancreatic Cancer, Sarah Gitto

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Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure, Julie Horton

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Downregulation in IFNGR1 Increases Suspectiblity to Mycobacterium Avium Subspecies Paratuberculosis Infection in Crohn's Disease, Zin Mar Htun

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The Microbial Ecosystem of Beer Spoilage and Souring: Competition and Cooperation in the Age of Bioinformatics, Andrew Kettring

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Discovery and Characterization of Antimalarials with Novel Mechanisms of Action, Bracken Roberts

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Discovery and Characterization of Novel Antimicrobials against Mycobacterium tuberculosis, Carolina Rodrigues Felix

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The Actin-Severing Protein Cofilin Is Downstream Of Neuregulin Signaling, Is Regulated By The Tumor Suppressor Merlin, And Is Essential For Schwann Cell Myelination, Nicklaus Sparrow

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Cathepsin B Regulates VLDL Secretion Through LFABP Cleavage, Simeon Thibeaux

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A Chemical and Genetic Approach to Study the Polyamine Transport System in Drosophila, Minpei Wang

Theses/Dissertations from 2016

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Could Dietary Peroxidized Lipids provoke an Intestinal Inflammatory Response?, Mitsushita Doomra

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The mauC gene encodes a versatile signal sequence and redox protein that can be utilized in native and non-native protein expression and electron trnasfer systems, Brian Dow

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Pyroglutamylated amyloid beta peptides enhance non-fibrillogenic aggregation of the unmodified peptide, Gregory Goldblatt

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Apolipoprotein-AI Regulates Hepatic VLDL Secretion by Controlling Intracellular VLDL-Trafficking, Bhavesh Gurwani

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VO-OHpic Treatment Reduces Cardiac Remodeling in Doxorubicin-Induced Cardiomyopathy, Taylor Johnson

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The Role of SOD1 Acetylation in Neurodegeneration, Michael Kaliszewski

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The Role of Type-I Interferon in Limiting Spread and Killing of an Oncolytic RNA Virus in Prostate Cells, Kritika Kedarinath

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Role of Kruppel-like Factor 8 (KLF8) in Cancer and Cardiomyopathy, Satadru Lahiri

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Neurological profile of older ApoE-PON1 double knockout mice, Connie Mitra

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Role of KLF8-CXCR4 signaling in Breast Cancer Metastasis, Debarati Mukherjee

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Involvement of miRNAs in the Development of Androgen Independent Prostate Cancer, Richard Ottman

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Chlamydia trachomatis Transformants Show a Significant Reduction in Rates of Invasion upon Removal of Key Tarp Domains, Christopher Parrett

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Malondialdehyde (MDA) and Glutathione Peroxidase (GPx) are Elevated in Crohns Disease-Associated with Mycobacterium Avium Subspecies Paratuberculosis (MAP), Ahmad Qasem

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Structural and functional characterization of enzymes of a novel group of tryptophylquinone cofactor containing oxidases, Esha Sehanobish

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BMP-7 Inhibits p38 and JNK Pathways and Increases M2 Macrophage Differentiation to Reduce Atherosclerosis in Apolipoprotein E-/- Mice, Heidi Shoulders

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The development of motuporamine derivatives and an investigation into their biological properties, Kristen Skruber

Theses/Dissertations from 2015

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TIMP-1 Activates a Unique Cardiac Stem Cell Population, CD63+ve/C-KIT+ve, Thereby Enhancing Cardiac Differentiation, and Protects the Heart From Adverse Cardiac Remodeling Following Myocardial Infarction, Latifa Abdelli

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Differential Expression Of Proteins Involved In VLDL Trafficking Causes Reduced VLDL Secretion In Male Ames Dwarf Mice, Faisal Ahmed Moinuddin

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Diabetes Phenotypes in Transgenic Pancreatic Cancer Mouse Models, Toya Albury-Warren

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Evaluation of Intestinal Microbial Diversity and a New Antibiotic Regimen in Crohn's Disease Patients, Karel Alcedo

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The CT20 peptide as an agent for cancer treatment, Rania Bassiouni

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Synthesis and Characterization of Antimicrobial Non-Color Forming Silica-Silver Nanocomposite, Joshua Bazata

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Synthesis and Characterization of Core-Shell Zinc Silica Nanoparticles and Zinc Silica Nanogels for Agricultural Applications., Megan Berroth

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Development of human and rodent based in vitro systems toward better translation of bench to bedside in vivo results, Bonnie Berry

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A Binary Approach for Selective Recognition of Nucleic Acids and Proteins, Evan Cornett

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FMF assay for assessing vaccine generated antibodies in a biomimetic manner, Vipra Dhir

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Membrane topology of a broad-spectrum resistance factor responsible for lipid modification in Enterococcus faecium., Jesse Harrison

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Overexpression of human Cu/Zn Superoxide Dismutase in Mice; The Effect of Increase Superoxide Scavenging on Autonomic Control of the Heart., Jeffrey Hatcher

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Functional Identification of Nucleus Tractus Solitarius (NTS) Barosensitive Neurons: Effect of Chronic Intermittent Hypoxia (CIH), Jenya Kolpakova

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A high-content multiplexed screening platform for the evaluation and manipulation of force and fatigue of adult derived skeletal muscle myotubes in defined serum-free medium, Christopher McAleer

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The role of a highly conserved eubacterial ribosomal protein in translation quality control, Anusha Naganathan

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Genetically-programmed suicide of adrenergic cells in the mouse leads to severe left ventricular dysfunction, impaired weight gain, and symptoms of neurological dysfunction, Aaron Owji

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Development of Cytotoxic Natural Killer Cells for Ovarian Cancer Treatment, Veethika Pandey

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Proteomic Analysis Delineates the Signaling Networks of Plasmodium falciparum, Brittany Pease

Theses/Dissertations from 2014

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Preparation, Characterization, and Delivery of Antibodies Binding to a Model Oncogenic RNA, Human Initiator tRNA, Jennifer Archer

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Role of Cardiac Catecholamines in Embryos and Adults Under Stress, Candice Baker

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Modulation of cholera toxin structure and function by host proteins, Helen Burress

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The Anti-toxin Properties of Grape Seed Phenolic Compounds, Patrick Cherubin

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Amyotrophic Lateral Sclerosis: mechanism behind mutant SOD toxicity and improving current therapeutic strategies, Cassandra Dennys

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Cerium oxide Nanoparticles: Their Phosphatase Activity and its Control, Atul Dhall

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Genetic and biochemical characterization of the roles of two putative purine transporters in the infectious cycle of Borrelia burgdorferi, Sunny Jain

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In Vitro Characterization of Unmodified and Pyroglutamylated Alzheimer's Amyloid beta peptide, Jason Matos

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Host and Bacterial Determinants of Staphylococcus aureus Nasal Colonization in Humans, Gowrishankar Muthukrishnan

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Purification and Characterization of a Novel Selenocysteine Lyase from Enterococcus faecalis, Samantha Nelson