While the clinical communities are aware of the prevalence of posttraumatic stress disorder (PTSD) among OEF/OIF/OND veterans, further efforts are necessary to bolster comprehensive strategies for assessment and treatment. The purpose of this study was to investigate whether a combat-related PTSD symptom provocation paradigm would elicit unique neurological responses via functional near-infrared spectroscopy across three groups – combat veterans with PTSD, combat veterans without PTSD, and nonmilitary participants without PTSD. Results indicated that combat veterans with PTSD demonstrated significant activation during exposure to a trauma-related sound compared to nonmilitary personnel at channels 14 (d = 1.03) and 15 (d = 1.30) and combat veterans without PTSD at channel 14 (d = 0.87). Specifically, this increased neural activation was approximately located in the right superior/medial prefrontal cortex (BA 9/10), associated with evaluating cue-familiarity and emotional detachment. Results were less clear with respect to a combat-related odor. These results suggest a specific neurophysiological response to trauma-related cues and if replicated, may offer a biomarker for combat-related PTSD. Such a response could provide incremental validity over diagnostic assessments alone and assist in planning and monitoring of treatment outcome.
If this is your thesis or dissertation, and want to learn how to access it or for more information about readership statistics, contact us at STARS@ucf.edu
Master of Science (M.S.)
College of Sciences
Length of Campus-only Access
Masters Thesis (Open Access)
Gramlich, Michael, "Posttraumatic Stress Disorder or Combat Experience? A Functional Near-infrared Spectroscopy Study of Trauma-related Auditory and Olfactory Cues" (2017). Electronic Theses and Dissertations. 5412.
Restricted to the UCF community until May 2017; it will then be open access.