An improved synthesis of O-benzoyl protected hydroxamates
Abbreviated Journal Title
J. Org. Chem.
BIOLOGICAL PROPERTIES; BIOSYNTHESIS; SIDEROPHORE; NANNOCHELIN; INHIBITORS; Chemistry, Organic
Several primary amines (R-NH2) were converted to their corresponding O-benzoyl protected hydroxamates under biphasic conditions. The intermediate (benzoyloxy)amines (R-NHOCOPh) were generated using benzoyl peroxide dissolved in CH2Cl2 and an aqueous carbonate buffer (pH 10.5) at room temperature. Subsequent acylation with R'COCl gave the protected hydroxamates (R'CONROCOPh) in good overall yields (56-89%).
Journal of Organic Chemistry
"An improved synthesis of O-benzoyl protected hydroxamates" (1997). Faculty Bibliography 1990s. 2128.