Title

Identification Of A Family Of Rab G-Proteins In Plasmodium Falciparum And A Detailed Characterisation Of Pfrab6

Authors

Authors

F. A. deCastro; G. E. Ward; R. Jambou; G. Attal; V. Mayau; G. Jaureguiberry; C. BraunBreton; D. Chakrabarti;G. Langsley

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Mol. Biochem. Parasitol.

Keywords

Rab GTPases; Rab6, traffic; secretion; Plasmodium falciparum; malaria; BINDING PROTEIN; GOLGI; TRANSPORT; PARASITE; GTPASES; GLYCOSYLATION; ERYTHROCYTES; EXPRESSION; CLONING; STAGE; Biochemistry & Molecular Biology; Parasitology

Abstract

As a first step towards developing a set of compartment-specific probes for studying protein trafficking in the malaria-infected erythrocyte, we describe here a family of Plasmodium falciparum Rab proteins. We characterise in detail P. falciparum Rab6 (PfRab6) a marker which in other cells is specific for the Golgi/trans Golgi network. Although PfRab6 mRNA is expressed throughout the intraerythrocytic cycle, maximal expression occurs at the trophozoite stage. Immunofluorescence microscopy shows that the distribution of PfRab6 changes during the final stages of parasite maturation, coalescing into multiple foci, each of which is associated with the nucleus of a forming daughter parasite.

Journal Title

Molecular and Biochemical Parasitology

Volume

80

Issue/Number

1

Publication Date

1-1-1996

Document Type

Article

DOI Link

http://dx.doi.org/10.1016/0166-6851(96)02670-9

Language

English

First Page

77

Last Page

88

WOS Identifier

WOS:A1996VG23700007

ISSN

0166-6851

Recommended Citation

"Identification Of A Family Of Rab G-Proteins In Plasmodium Falciparum And A Detailed Characterisation Of Pfrab6" (1996). Faculty Bibliography 1990s. 3032.
https://stars.library.ucf.edu/facultybib1990/3032