Title

Nucleic Acid Detection using MNAzymes

Authors

Authors

Y. V. Gerasimova;D. M. Kolpashchikov

Comments

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Abbreviated Journal Title

Chem. Biol.

Keywords

DNA ENZYME; Biochemistry & Molecular Biology

Abstract

Deoxyribozymes are promising biotechnological tools. In a recent JACS article, Mokany et al. reported on the design of multi-component deoxyribozyme (MNAzyme) sensors based on 10-23 and 8-17 DNA enzymes. The sensors can detect down to 5 pM of a specific nucleic acid. The versatility of MNAzyme platform allows the design of catalytic cascades for signal amplification. This work is a step forward to PCR-free molecular diagnostics.

Journal Title

Chemistry & Biology

Volume

17

Issue/Number

2

Publication Date

1-1-2010

Document Type

Editorial Material

Language

English

First Page

104

Last Page

106

WOS Identifier

WOS:000275897400004

ISSN

1074-5521

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