Authors

V. Gulati;R. Wallace

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Abbreviated Journal Title

Nanomaterials

Keywords

rafts; nanoparticles; nanomedicine; neural disease; epilepsy; Parkinson's disease; Alzheimer's disease; liposomes; solid lipid; nanoparticles; AMYLOID PRECURSOR PROTEIN; SOLID LIPID NANOPARTICLES; BLOOD-BRAIN-BARRIER; GPI-ANCHORED PROTEINS; APP TRANSGENIC MICE; ALPHA-SYNUCLEIN; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; NMDA RECEPTOR; THERAPEUTIC TARGET; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary

Abstract

This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiologies of three major neural diseases-epilepsy, Parkinson's disease, and Alzheimer's disease-selected as promising candidates for raft-based therapeutics. Raft-targeting drug delivery systems involving liposomes and solid lipid nanoparticles are then examined in detail.

Journal Title

Nanomaterials

Volume

2

Issue/Number

3

Publication Date

1-1-2012

Document Type

Review

Language

English

First Page

217

Last Page

250

WOS Identifier

WOS:000209072500001

ISSN

2079-4991

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