Tyrosine nitration as mediator of cell death
Abbreviated Journal Title
Cell. Mol. Life Sci.
Tyrosine nitration; Cell death; Reactive nitrogen species; Peroxynitrite; Nitrated Hsp90; MANGANESE-SUPEROXIDE-DISMUTASE; PEROXYNITRITE-INDUCED APOPTOSIS; AMYOTROPHIC-LATERAL-SCLEROSIS; NITRIC-OXIDE SYNTHASE; LIVER; PLASMA-MEMBRANE; SPINAL-CORD-INJURY; DEPENDENT PROTEIN NITRATION; ALZHEIMERS-DISEASE BRAIN; OXIDATIVE STRESS; CYTOCHROME-C; Biochemistry & Molecular Biology; Cell Biology
Nitrotyrosine is used as a marker for the production of peroxynitrite and other reactive nitrogen species. For over 20 years the presence of nitrotyrosine was associated with cell death in multiple pathologies. Filling the gap between correlation and causality has proven to be a difficult task. Here, we discuss the evidence supporting tyrosine nitration as a specific posttranslational modification participating in the induction of cell death signaling pathways.
Cellular and Molecular Life Sciences
"Tyrosine nitration as mediator of cell death" (2014). Faculty Bibliography 2010s. 2592.