Title

The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages

Authors

Authors

S. P. Huang; D. F. Qi; J. Liang; R. D. Miao; K. Minagawa; T. Quinn; T. Matsui; D. P. Fan; J. G. Liu;M. G. Fu

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Cell. Signal.

Keywords

Macrophage; Toll-like receptor; Signal transduction; JNK; NF-kappa B; ATHEROSCLEROTIC LESION DEVELOPMENT; FOLLICULAR LYMPHOMA; CELL LYMPHOMA; KAPPA-B; ACTIVATION; DISEASE; GENE; Cell Biology

Abstract

Toll-like receptors (TLR) are pivotal in macrophage activation. The molecular mechanisms controlling TLR signaling and macrophage activation are not completely understood. Zc3h12d is originally identified as a possible tumor suppressor gene. However, its function remains unknown. We here report that Zc3h12d negatively regulates TLR signaling and macrophage activation. Zc3h12d was enriched in spleen, lung and lymph node. In macrophages, the expression of Zc3h12d was remarkably induced by TLR ligands through JNK and NF-kappa B signal pathways. On the other hand, overexpression of Zc3h12d significantly inhibited TLR2 and TLR4 activation-induced JNK, ERK and NF-kappa B signaling as well as macrophage inflammation. Similar to Zc3h12a/MCPIP1. Zc3h12d also decreased the global cellular protein ubiquitination. These findings suggest that Zc3h12d is a novel negative feedback regulator of TLR signaling and macrophage activation and thus may play a role in host immunity and inflammatory diseases. (C) 2011 Elsevier Inc. All rights reserved.

Journal Title

Cellular Signalling

Volume

24

Issue/Number

2

Publication Date

1-1-2012

Document Type

Article

Language

English

First Page

569

Last Page

576

WOS Identifier

WOS:000299971500025

ISSN

0898-6568

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