Non-phosgene route to unsymmetrical ureas from N-Cbz-alpha-amino acid amides
Abbreviated Journal Title
Urea synthesis; Rearrangement; Non-phosgene; alpha-Amino acid amides; BETA-SHEET LIGANDS; ALZHEIMERS-DISEASE; CARBON-DIOXIDE; OXIDATIVE; CARBONYLATION; TETRASUBSTITUTED UREAS; DERIVATIVES; EFFICIENT; ANTAGONISTS; INHIBITORS; DESIGN; Chemistry, Organic
A convenient method toward the synthesis of alpha-amino acid-derived unsymmetrical ureas 2 is described herein. This route involves an interesting rearrangement of amides of N-Cbz-alpha-amino acids 1, which pre-sumably entails the intermediacy of hydantoins that is followed by hydrolysis to afford unsymmetrical ureas 2 in quantitative yields and high purity. (C) 2013 Elsevier Ltd. All rights reserved.
"Non-phosgene route to unsymmetrical ureas from N-Cbz-alpha-amino acid amides" (2013). Faculty Bibliography 2010s. 4919.