Proteome-genome complexity as a metric of refractory disease
Abbreviated Journal Title
Refractory disease; Proteomics; Genomics; Network medicine; Boolean; networks; Complexity; Biochemical Research Methods
Treatment decisions for refractory diseases are frequently challenging because the benefits of disease-free survival and relief of symptoms must be balanced against the severity and frequency of side effects. A precise measure of disease resistance would therefore be valuable when assessing possible treatment strategies. In recent years there has been much interest in the modeling of proteomes and genomes as a means of identifying major pathways of disease causation. We suggest that these analyses may offer the additional benefit of quantifying refractory. (C) 2014 Elsevier B.V. All rights reserved.
Journal of Proteomics
"Proteome-genome complexity as a metric of refractory disease" (2014). Faculty Bibliography 2010s. 5399.