Title

Numerical Surrogates for Human Observers in Myocardial Motion Evaluation From SPECT Images

Authors

Authors

T. Marin; M. M. Kalayeh; F. M. Parages;J. G. Brankov

Comments

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Abbreviated Journal Title

IEEE Trans. Med. Imaging

Keywords

Cardiac motion; cardiac-gated single photon emission computed; tomography; image quality; machine learning; model observers; numerical; observer; PERFUSION SPECT; LEFT-VENTRICLE; GATED SPECT; MATHEMATICAL-MODEL; HOTELLING OBSERVER; DETECTION ACCURACY; RECONSTRUCTION; COMPENSATION; OPTIMIZATION; QUANTITATION; Computer Science, Interdisciplinary Applications; Engineering, ; Biomedical; Engineering, Electrical & Electronic; Imaging Science &; Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging

Abstract

In medical imaging, the gold standard for image-quality assessment is a task-based approach in which one evaluates human observer performance for a given diagnostic task (e. g., detection of a myocardial perfusion or motion defect). To facilitate practical task-based image-quality assessment, model observers are needed as approximate surrogates for human observers. In cardiac-gated SPECT imaging, diagnosis relies on evaluation of the myocardial motion as well as perfusion. Model observers for the perfusion-defect detection task have been studied previously, but little effort has been devoted toward development of a model observer for cardiac-motion defect detection. In this work, we describe two model observers for predicting human observer performance in detection of cardiac-motion defects. Both proposed methods rely on motion features extracted using previously reported deformable mesh model for myocardium motion estimation. The first method is based on a Hotelling linear discriminant that is similar in concept to that used commonly for perfusion-defect detection. In the second method, based on relevance vector machines (RVM) for regression, we compute average human observer performance by first directly predicting individual human observer scores, and then using multi reader receiver operating characteristic analysis. Our results suggest that the proposed RVM model observer can predict human observer performance accurately, while the new Hotelling motion-defect detector is somewhat less effective.

Journal Title

Ieee Transactions on Medical Imaging

Volume

33

Issue/Number

1

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

38

Last Page

47

WOS Identifier

WOS:000331296800004

ISSN

0278-0062

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