Title

Inhibition of Nanoceria's Catalytic Activity due to Ce3+ Site-Specific Interaction with Phosphate Ions

Authors

Authors

R. N. McCormack; P. Mendez; S. Barkam; C. J. Neal; S. Das;S. Seal

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

J. Phys. Chem. C

Keywords

CERIUM OXIDE NANOPARTICLES; DIFFUSE-REFLECTANCE; CANCER CELLS; REDOX; STATE; OXYGEN; ANTIOXIDANT; RADIATION; TOXICITY; SURVIVAL; PROTECT; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, ; Multidisciplinary

Abstract

Cerium oxide nanoparticles (CNPs) exhibit superoxide dismutase (SOD) and catalase mimetic activities. Therefore, based on its catalytic activities, CNPs can potentially be used to treat diseases associated with oxidative stress. The potency of CNPs can be hindered by ion interaction due to chemical modifications. The issue is that phosphate ions are relatively ubiquitous in all biological relevance medium and body fluid. Our ventures in this study were to understand the phosphate ion interaction and fabricate CNPs that are biocompatible and simultaneously retain their catalytic properties in the presence of phosphate ions. CNPs were coated with polyethylene glycol and dextran in order to enhance biocompatibility. A series of experiments determined that maximizing the preserved catalytic responses were highly dependent on the Ce3+:Ce4+. Results have shown that the particles engineered with higher concentrations of Ce4+ on the surface are more robust and retain catalytic activity post buffer exposure.

Journal Title

Journal of Physical Chemistry C

Volume

118

Issue/Number

33

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

18992

Last Page

19006

WOS Identifier

WOS:000340809600020

ISSN

1932-7447

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