Title
Improved Synthesis of the Triazacryptand (TAC) and its Application in the Construction of a Fluorescent TAC-BODIPY Conjugate for K+ Sensing in Live Cells
Abbreviated Journal Title
Eur. J. Org. Chem.
Keywords
Potassium; Sensors; Cryptands; Fluorescence; Cell imaging; INTRACELLULAR POTASSIUM; CHANNELS; SENSOR; SODIUM; CANCER; PBFI; INDICATOR; APOPTOSIS; TRANSPORT; Chemistry, Organic
Abstract
In this report, a vastly improved method for the synthesis of [2.2.3]-triazacryptand (TAC), an excellent K+-selective cryptand, is disclosed, which provides a shorter synthetic route with > fivefold higher overall yield. On the basis of the improved synthesis, a TAC-BODIPY conjugate was developed for K+ sensing. TAC-BODIPY is a fluorescence turn-on K+ sensor exhibiting high selectivity toward K+ over other biologically relevant metal cations. Cell imaging studies are presented and demonstrate that TAC-BODIPY is suitable for dynamic K+ sensing in live cells.
Journal Title
European Journal of Organic Chemistry
Issue/Number
6
Publication Date
1-1-2015
Document Type
Article
Language
English
First Page
1189
Last Page
1192
WOS Identifier
ISSN
1434-193X
Recommended Citation
"Improved Synthesis of the Triazacryptand (TAC) and its Application in the Construction of a Fluorescent TAC-BODIPY Conjugate for K+ Sensing in Live Cells" (2015). Faculty Bibliography 2010s. 6815.
https://stars.library.ucf.edu/facultybib2010/6815
Comments
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