Keywords
nanomedicine; theranostics; cancer; bioimaging; superparamagnetic; core-shell nanoparticles
Abstract
This study presents the synthesis and comprehensive characterization of a novel core-shell nanoparticle composed of a maghemite (γ-Fe2O3) core and a europium-doped cerium oxide (EuCNP) shell, developed for potential use in cancer theranostics. Using a co-precipitation method, Fe2O3–EuCNP core-shell nanoparticles were synthesized and compared against control samples of CNPs, EuCNPs, and Fe2O3. A variety of characterization techniques, including UV-Vis spectroscopy, fluorescence spectroscopy, TEM, XRD, XPS, DLS, TGA, and DSC confirmed the successful synthesis of core-shell architecture and europium doping. Moreover, Fe2O3–EuCNPs demonstrating strong colloidal stability (high zeta potential), enhanced Ce3+ content, and enhanced photoluminescence. RAW 264.7 macrophages cells showed good cell viability after incubating with the nanoparticles, while MCF-7 breast cancer cells showed relatively greater cell death. The multifunctionality of these nanoparticles—combining magnetic, antioxidant, and fluorescent properties—positions them as promising candidates for future development in magnetic hyperthermia treatment, magnetic drug targeting, and optical imaging in cancer therapy.
Thesis Completion Year
2025
Thesis Completion Semester
Spring
Thesis Chair
Seal, Sudipta
College
College of Engineering and Computer Science
Department
Materials Science and Engineering; Burnett School of Biomedical Sciences
Thesis Discipline
Nanomedicine
Language
English
Access Status
Open Access
Length of Campus Access
None
Campus Location
Orlando (Main) Campus
STARS Citation
Patel, Ishaan, "Synthesis and Characterization of Multifunctional Cerium Oxide Containing Nanoparticles for Biomedical Applications" (2025). Honors Undergraduate Theses. 278.
https://stars.library.ucf.edu/hut2024/278
Included in
Biology and Biomimetic Materials Commons, Biomaterials Commons, Nanomedicine Commons, Oncology Commons
Rights Statement
