Keywords
cardiovascular disease; HIV; comorbidities; metabolism; Tg26; indirect calorimetry
Abstract
Obesity and related comorbidities, such as cardiovascular disease, have been increasing globally, with more than two-thirds of the 4.0 million deaths in 2015 caused by cardiovascular disease (Powell-Wiley, 2021). With the global obesity epidemic and related comorbidities, including cardiovascular disease, increasing every year, it has become crucial to ensure that we target high risk populations. A recent analysis found that people living with HIV have more than twice the risk of cardiovascular disease, compared to those without HIV (So-Armah et al., 2020). This study will compare metabolic differences across genders and genotypes in mature Tg26 transgenic mice via indirect calorimetry. We hypothesize that Tg26 mice will exhibit lower RERs due to their reduced ability to utilize carbohydrates in early ages, with decreasing effects with age and greater kidney injury and muscle wasting. This study will improve our understanding of gender and age-related metabolic changes associated with people living with HIV.
Thesis Completion Year
2025
Thesis Completion Semester
Spring
Thesis Chair
Gupta, Manish
College
College of Medicine
Department
Burnett School of Biomedical Sciences
Thesis Discipline
Biomedical Sciences
Language
English
Access Status
Campus Access
Length of Campus Access
5 years
Campus Location
Orlando (Main) Campus
STARS Citation
Kimura, Yuka, "Determination Of Hiv-Induced Metabolic Complication Using Hiv-1 Transgenic Mice" (2025). Honors Undergraduate Theses. 282.
https://stars.library.ucf.edu/hut2024/282
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