A collection of Medicine Masters Theses and Doctoral Dissertations.

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Theses/Dissertations from 2022

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Attenuation of Excess TNFα Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGFβ-mediated Immunosuppression Through the Modulation of TACE Trafficking, Taylor Louis

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Evaluating Novel Combinations of Polyamine Targeting Therapeutics in Pancreatic Ductal Adenocarcinoma, Sai Preethi Nakkina

Theses/Dissertations from 2021

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Downregulation of miR-34a via Calorie Restriction Regulates Lipid Metabolism in the Liver of Long-living Ames Dwarf Mice, Sarah Ashiqueali

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Investigating the Role of the Skeletal Muscle in Amyotrophic Lateral Sclerosis Neuromuscular Junction Dysfunction, Agnes Badu-Mensah

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Chitosan-Gallium Nanocomposite: Synthesis, Characterization and Antibacterial Activity, Samjhana Bhandari

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Modulation of Fat Taste by Diet and Hormones, Ashley Calder

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Regulation of Actin Assembly, Mechanics, and Structure by Intracellular Environmental Factors, Nicholas Castaneda

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Sex Differences in Peripheral Fat Detection and Metabolism, Naima Dahir

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Doxorubicin-Induced Differential Patterns of Cell Death in the Skeletal Muscle, Fatima Bianca Dessouki

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Reassessing the Transcriptional Regulation of Protective CD4 T Cell Responses Against Influenza A Virus, Kunal Dhume

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Anti-MAP Triple Therapy Supports Immunomodulatory Therapeutic Response in Crohn's Disease Through Downregulation of NF-kB Activation in the Absence of MAP Detection, Erij Elkamel

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Transcriptomic Analyses Reveal Distinct Responses of Differentiated and Poorly-differentiated Intestinal Epithelial Cells to Lipid Peroxides, Nisreen Faizo

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The Consequence of Loss of Expression of AR-targeting MicroRNAs in Prostate Cancer Progression, Kavya Ganapathy

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Chaperonin-containing TCP1 Complex (CCT) Promotes Breast Cancer Uncontrolled Growth, Heba Ghozlan

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Novel Mechanisms Underlying Drug-resistant Metastasis and Relapse in Breast Cancer, Jie Hao

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Influence of Geography on the Healthy Gut Microbiome and the Role of the Gut Microbiome in IBD Symptom and Disease Progression, Sayf Al-Deen Hassouneh

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Investigating Effects of Ribosomal Occupancy on the Production of the Clamp Loader Subunits Tau and Gamma, Akhmetzada Kargazhanov

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Effects of Endogenous E. coli Molecules on Translational Fidelity, Piotr Lagod

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Bacterial Association Networks from Healthy and Cancer-associated Gut Microbiomes, Mark Loftus

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Utilization of HBPE Nanoparticles for Optimizing Drug Delivery to Cancer Cells, Daniel Nierenberg

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Characterization of a Cell Migration Defect in Drosophila melanogaster Border Cells in Response to the Chlamydia trachomatis TepP Effector, Kayli Rohal

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Competence Transcriptome Changes in Streptococcus Pneumoniae, Smitha Shambhu

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Spermidine Rescued PTPN2/22 Function in CRISPR-Cas9-edited T-cells with PTPN2/22 SNPs Linked to Crohn's Disease and Rheumatoid Arthritis, Ameera Shaw

Theses/Dissertations from 2020

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Monitoring Pathological Gene Expression and Studying Endogenous Epigenetic Architecture by CRISPR/Cas9-based Tool Development using alpha-Synuclein as a Model, Levi Adams

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Optimization of Cryopreserved Memory CD4 T Cell Mediated Protection against Lethal Influenza A Virus Infection in Mice, Fahmida Alam

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The Role of Nicotine in Exacerbating The Inflammatory Response in Macrophages Infected with Mycobacterium avium paratuberculosis in Crohn's Disease Smokers, Dania Alqasrawi

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Copper/N-acetylcysteine Coated Iron Oxide Nanoparticles Synthesis, Characterization, and Antimicrobial Activities, Danya Belnour

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HIV Infection in Women: Novel Approaches for Prevention, Michelle Cherne

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Early Host Defense Mechanisms against La Crosse Virus Infection, Maria A. Cruz Zamora

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Single Cell Forensic Genomics - DNA Profiling of Micromanipulated Single Spermatozoa, Haley Hardin

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Gelsolin-Mediated Actin Filament Severing in Crowded Environments, James Heidings

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The Role of Notch1, IL-6 and miR-146a in Inflammation and Infection in Crohn's Disease Non-Responders to Anti-TNF-Alpha Therapy, Esra'a Keewan

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Mapping of the Rat Intrinsic Cardiac Nervous System in 3D Reconstructed Hearts, Clara Leung

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The Innate Immune Response to House Dust Mite in Allergic Airway Inflammation, Madelyn Miller

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Identification of Novel Antimalarials From Natural Product Inspired Libraries, David Perry

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Novel Roles of RIP2 in Inflammation and Resolution, Michael Shehat

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Chaperonin-containing TCP-1 Modulates Breast Cancer Growth and Malignancy, Anne Showalter

Theses/Dissertations from 2019

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AB Toxins: Recovery from Intoxication and Relative Potencies, Patrick Cherubin

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Alpha-Tocopherol Reduces VLDL Secretion Through Modulation of the VLDL Transport Vesicle, Ryan Clay

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A Cytoplasmic-Replicating RNA Virus Sensitizes Cancer Cells to DNA Modifying Agents, Candace Fox

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Bone Morphogenetic Protein 7 Inhibits Pyroptotic Cell Death in Vascular Smooth Muscle Cells of Atherosclerotic Apolipoprotein E -/- Mice, Kaley Garner

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Multi-target High-throughput Screening Assays for Antimicrobial Drug Discovery, Christopher Grube

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Unraveling PDI and its Interaction with AB Toxins, Jessica Guyette

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Identification and Functional Characterization of a Long Non-coding RNA associated with Prostate Cancer, Md Faqrul Hasan

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ATP Induced Molecular Disassembly of Cytolethal Distending Toxin's B/C Heterodimer, George Huhn

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Synthesis and Bioevaluation of Methionine Depletion Agents, Houssine Ikhlef

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Phenotypic and Molecular Characterization of the Emergent Marine Pathogen Vibrio vulnificus, Jane Maureen Jayakumar

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Selenium vs. Sulfur: Investigating the Substrate Specificity of a Selenocysteine Lyase, Michael Johnstone

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It Takes Two to Tango: The Toxin-chaperone Relationship, Alisha Kellner

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Use of Artificial Intelligence for Malaria Drug Discovery, Arash Keshavarzi Arshadi

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Zika Virus-induced Lysis of Cervical Cancer Cells, Harini Krishnapura

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Unraveling the Role of Phenylethanolamine N-methyltransferase (Pnmt+) Cells In-vivo, Sanjana Manja

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Motor and Sensory Characterization of a Mouse Model of Charcot-Marie-Tooth Type 2O Disease, Swaran Nandini

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Role of TNFα Antagonists and Genetic Polymorphisms in Modulating Susceptibility to Mycobacterial Infection among Patients with Crohn's Disease, Ahmad Qasem

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Allelic Characterization and Novel Functions of the Outer Membrane Porin U in Vibrio Cholerae, Sk Nazmus Sakib

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Metabolic Effects of 17a-Estradiol are Growth Hormone Independent and Sex Specific, Silvana Sidhom

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Determining Differential Effects of Interleukin-2 on Innate and Adaptive Immune Cells in Lymphoid Organs and the Gastrointestinal Tract, Ayushi Singh

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Mechanism of NANOGP8 in Glioblastoma Multiforme, Jonhoi Smith

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Biochemical Characterization of Rv2633c from Mycobacterium tuberculosis and the Effects of Mutagenesis on Iron Binding, Kyle Strickland

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Investigating Changes in Quiescence in Oral and Esophageal Epithelium in Response to Injury, Alexandra Troia

Theses/Dissertations from 2018

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Development of a Functional In Vitro 3D Model of the Peripheral Nerve, Wesley Anderson

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Regulation of Extra-Pituitary Prolactin in Monocytes and Macrophages, Richard Barrett

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Knowledge and Attitudes Regarding the Recent Zika Outbreak Among a Sample of South Florida Residents, Mohamed Elakkari

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Dissecting the Components of Neuropathic Pain, Dale George

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Embryonic Stem Cell Derived Exosomes Enhance Cardiac Stem Cell Differentiation into Heart Cells, Jamillah Hammond

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Role of Mycobacterium avium paratuberculosis (MAP) and TNFSF15 SNPs on TL1A in CD, Sayf Al-Deen Hassouneh

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Development of a Non-Human Primate Model for Staphylococcus aureus Nasal Carriage, Amanda Lasseter

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Deciphering the Role of Adrenergic Hormones in Embryonic Cardiac Calcium Signaling and Metabolism, Jessica Peoples

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Role of Lipid Peroxide Derived Dicarboxylic Acids in Atherosclerotic Calcification, Aladdin Riad

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Characterization of Neural Cells Derived from Reelin-deficient Schizophrenic Patient iPS Cells, Nicole Roberts

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Neuromuscular Junction Defects in a Mouse Model of Charcot-Marie-Tooth Disease Type 2O, Thywill Sabblah

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PG-VTV Biogenesis Requires ATP to Facilitate Phosphorylation of Syntaxin 17, Anika Saxena

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Role of Single Nucleotide Polymorphisms (SNPs) in PTPN2/22 and Mycobacterium Avium Subspecies Paratuberculosis (MAP) in Rheumatoid Arthritis and Crohn's Disease, Robert Sharp

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Embryonic Stem Cell-Derived Exosomes Inhibit Doxorubicin-Induced Pyroptosis in Cell Culture Models, Zahra Tavakoli Dargani

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Exacerbation of ΔEFP Sickness in Escherichia coli By an Uncharacterized RNA Helicase, Robert Wingo

Theses/Dissertations from 2017

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Characterization of Novel Borrelia burgdorferi Transcripts Expressed during Tick and Mammalian Infection, Philip Adams

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A Major DNA Double Strand Repair Pathway and Cancer-Associated Circulating Proteins are Effecters of Epigenetic Revision., Brittany Allen

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Implication of Alpha-synuclein Transcriptional Regulation and Mutagenesis in the Pathogenesis of Sporadic Parkinson's Disease, Sambuddha Basu

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Development of Molecular Diagnostic Tools for Mycobacterium Species, Hillary Bengtson

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Chaperonin Containing TCP1 (CCT) as a Target for Cancer Therapy, Ana Carr

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Plasticity of Central and Peripheral Nervous System: Effects of Oxygen-Glucose Deprivation (OGD) and Chronic Intermittent Hypoxia (CIH), Jin Chen

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Targeted Therapy Development for Neurofibromatosis Type 2, Marisa Fuse

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Novel Cytokine Signaling and Molecular Therapeutic Strategy in Pancreatic Cancer, Sarah Gitto

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Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure, Julie Horton

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Downregulation in IFNGR1 Increases Suspectiblity to Mycobacterium Avium Subspecies Paratuberculosis Infection in Crohn's Disease, Zin Mar Htun

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The Microbial Ecosystem of Beer Spoilage and Souring: Competition and Cooperation in the Age of Bioinformatics, Andrew Kettring

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Discovery and Characterization of Antimalarials with Novel Mechanisms of Action, Bracken Roberts

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Discovery and Characterization of Novel Antimicrobials against Mycobacterium tuberculosis, Carolina Rodrigues Felix

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The Actin-Severing Protein Cofilin Is Downstream Of Neuregulin Signaling, Is Regulated By The Tumor Suppressor Merlin, And Is Essential For Schwann Cell Myelination, Nicklaus Sparrow

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Cathepsin B Regulates VLDL Secretion Through LFABP Cleavage, Simeon Thibeaux

Theses/Dissertations from 2016

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Could Dietary Peroxidized Lipids provoke an Intestinal Inflammatory Response?, Mitsushita Doomra

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The mauC gene encodes a versatile signal sequence and redox protein that can be utilized in native and non-native protein expression and electron trnasfer systems, Brian Dow

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Apolipoprotein-AI Regulates Hepatic VLDL Secretion by Controlling Intracellular VLDL-Trafficking, Bhavesh Gurwani

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VO-OHpic Treatment Reduces Cardiac Remodeling in Doxorubicin-Induced Cardiomyopathy, Taylor Johnson

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The Role of SOD1 Acetylation in Neurodegeneration, Michael Kaliszewski

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The Role of Type-I Interferon in Limiting Spread and Killing of an Oncolytic RNA Virus in Prostate Cells, Kritika Kedarinath

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Role of Kruppel-like Factor 8 (KLF8) in Cancer and Cardiomyopathy, Satadru Lahiri

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Neurological profile of older ApoE-PON1 double knockout mice, Connie Mitra

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Role of KLF8-CXCR4 signaling in Breast Cancer Metastasis, Debarati Mukherjee

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Involvement of miRNAs in the Development of Androgen Independent Prostate Cancer, Richard Ottman