A collection of Medicine Masters Theses and Doctoral Dissertations.

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Theses/Dissertations from 2024

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Cisplatin Induces Skeletal Muscle Toxicity and Adverse Muscle Remodeling Via Pyroptotic Cell Death, Chisom Nkemdirim Akaniru

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Epidemiological Insights of Covid-19: Understanding Variant Dynamics, Environmental Surveillance and Disparities in Florida, Md Sobur Ali

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Investigating Natural Proline-rich Antimicrobial Peptides (PrAMPs) Activity Towards Klebsiella pneumoniae, Ridhwana M. Appiah

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The Role of Cellular Senescence in Inflammatory Bowel Diseases (IBDs), Sarah A. Ashiqueali

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Cardiac and Skeletal Muscle Dysfunction in Diabetic Dyslipdemic mice is Mitigated by Stem Cell Derived Exosomes, Abha Banerjee

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Distribution and Morphology of CGRP-IR Axons in Flat-Mounts of Whole Rat Hearts and Whole Male/Female Mouse Atria, Kohlton T. Bendowski

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Application of Long-Read Sequencing in Microbiome Compositional Studies related to Disease, Noah Greenman

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Developing a Novel Gold Nanoparticle-based Colorimetric Assay for the Detection of Cytomegalovirus (CMV) in Pediatric-derived Urine Specimens, Sonam Gupta

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Exploring the Physiology of Clostridioides difficile: Selenium-Dependent Catabolism of Host-Derived Nutrients, Michael A. Johnstone

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Aquaporin 4 promotes Drug Tolerance to AMG 510 in KRASG12C mutant Non-Small Cell Lung Cancer, Nastassja G. Luna

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Probing Endothelial-to-Mesenchymal Transition Cellular Biomechanics, Marvin A. Mendoza Jr

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Investigating Lectin Mannose Binding 1 (LMAN1) as a Potential Regulator of Inflammatory Responses in Alternaria alternata-Induced Allergic Asthma, Faith Sauber

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Mycobacterium Avium Paratuberculosis Infection Suppresses Vitamin D Activation and Cathelicidin Production in Macrophages Through Modulation of the TLR2-dependent p38/MAPK-CYP27B1-VDR-CAMP Axis, Muna M. Talafha

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Identification of the Role of Protein Kinases in VLDL Trafficking, Fahim Rejanur Tasin

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Inhibitors of Amyloid Beta Oligomerization and Toxicity, Maria C. Zabala Rodriguez

Theses/Dissertations from 2023

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Mesenchymal Stem Cell Derived Exosomes Attenuates Doxorubicin-Induced Cardiotoxicity, Sawdah A. Ali

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Ponatinib-induced Cardiac Toxicity is Mediated by Impaired Angiogenesis, Imran Altiokka

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Topographical Distribution and Morphology of Sympathetic Postganglionic Innervation and Chronic Intermittent Hypoxia (CIH) Induced Remodeling of the Whole Heart at Single Cell/Axon/Varicosity Scale, Ariege Bizanti

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Repurposing of Human Protein Kinase Inhibitors Identifies Dual Stage Active Antimalarials, Monica J. Bohmer

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Identification and Influence of Species-Informative 16S Ribosomal RNA Sequences and Evaluation of Ocean Biofilms, Nikhil Bose

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Examining the Relationship between phiETA Susceptibility & Temperate Phage Diversity in Staphylococcus aureus, Atrayee Chatterjee

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Examining Novel Aspects of T-cell Priming and Lung Resident T-cell Function to Improve Vaccine Induced Protection Against Influenza A Virus, Caroline M. Finn

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Polyamine Blockade Therapy: Modulating Pancreatic Tumor Microenvironment and Role in MDSC Biology, Manav Gandhi

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Targeting Inhibitory Receptor TIGIT Signaling in NK Cells to Improve Anti-tumor Immunity, Md Faqrul Hasan

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Host Cell Responses Modulate Oncolytic Viral Treatment of Neuroblastoma Cells, Kritika Kedarinath

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Analysis of Acute Colitis in Mice Deficient for Master Regulators of Both Type-1 and Type-17 Inflammation Using Traditional Readouts and Metabolic and Behavioral Data, Rodney Long

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Comprehensive Imaging And Quantitative Analysis Techniques For Nociceptive Afferent Innervation Of The Stomach And Development Of A Micro Liquid Thermal Regulator (MLTR), Jazune Madas

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Identification of an Endogenous Multiprotein Complex Required to Generate the VLDL Transport Vesicle from the Hepatic ER, Rutuparnna Mishra

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Characterization of Snyder-Robinson Syndrome (SRS) in Mutant Mice and Treatment with a Novel Spermine Prodrug to Rebalance Intracellular Polyamine Levels, Deepshikha Mitra

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GATM is Involved in the Promotion of Drug Resistance in Lung Cancer, Nikitha Murugavel

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Mechanisms of Early-Stage Mutant EGFR-Driven Lung Cancer: The Role of Kynurenine, Alice Rodriguez-Fuguet

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Roles of Chlamydia Trachomatis Early Effector Proteins Tarp, TmeA, and TmeB in Host Cytoskeleton Remodeling During Invasion, Kaylyn R. Scanlon-Richardson

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New Tools and Platforms for Mosquito Behavior, Control and Bite-site Biology Investigations, Corey Seavey

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PDI's Function as a Disaggregase Uses a Novel Mechanism of Action, Albert A. Serrano

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Preclinical Assessment of Psychoplastogens for Treatment of Psychiatric Symptoms and Neuroplasticity Deficits in Huntington Disease, Nicholas Skiados

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Mechanisms by Which LMAN1 Regulates HDM-induced Allergic Inflammation, Lindsay Swaby

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Genotypic and Phenotypic Analysis of Pseudomonas aeruginosa from Respiratory Tract of Pediatric Patients, Wageha Talib

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Role of Vitamin D, Folate, and Cobalamin Deficiency in Mycobacterium avium Paratuberculosis Infection and Inflammation, Joseph Vaccaro

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Impact of R300 and C343 in the B' Domain of Protein Disulfide Isomerase on its Disaggregase Activity Against Cholera Toxin, Evie Vincent

Theses/Dissertations from 2022

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Delineating the Cytotoxic Mechanism of Purine Metabolite AICAR in Lung Cancer Cells, Fareesa Aftab

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Extracellular Vesicle-associated Biomolecules as Potential Biomarkers for Alzheimer's Disease Diagnosis, Lina Bedoya Martinez

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Discovery of Antiplasmodial Compounds From Fungi, Jennifer Collins

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Chaperonin Containing TCP-1 is a novel biomarker for cancer detection, Amanda Cox

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3D Microelectrode Arrays (MEAs) For The Study And Interrogation Of Electrogenic Cells In Fabricated Microenvironments, Charles Didier

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Development of Curcumin-loaded Nanoparticles for Drug Delivery Optimization in the Treatment of Peripheral Nerve Injury, Giuliana Giannelli

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Molecular Adaptations for Intestinal Colonization in Vibrio cholerae, Trudy-Ann Grant

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Evaluation of Magnesium Hydroxide Particles Coated with Betaine and Citrate as a Magnesium Delivery System for Migraine Treatment, Ashton Holderness

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Reexamining Cytolethal Distending Toxin's Host Cell Entry and Trafficking: The First Steps Down a Long Road, George Huhn

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Effects of PCSK9i on Doxorubicin Induced Necroptosis, Omonzejie Imaralu

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Functional Based Drug Discovery With Artificial Intelligence, Arash Keshavarzi Arshadi

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Attenuation of Excess TNFα Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGFβ-mediated Immunosuppression Through the Modulation of TACE Trafficking, Taylor Louis

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Reporter Chondrocyte Optimization of Bioinks for Zonal 3D Bioprinting of Cartilage, Kari Martyniak

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Investigating the Relationship Between the Microbiome and Neuroactive Metabolites in Huntington Disease Model Mice, Christian Millot

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Topographical Distribution and Morphology of Substance P Containing Nerves in the Flat-Mounts and Serial Sections of Mouse Whole Stomach at the Single Cell/Axon/Synapse Scale: A Comprehensive Study., Anas Jaser Mousa Mistareehi

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Evaluating Novel Combinations of Polyamine Targeting Therapeutics in Pancreatic Ductal Adenocarcinoma, Sai Preethi Nakkina

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Mapping the Organization and Morphology of Calcitonin Gene-Related Peptide (CGRP)-IR Axons in the Whole Mouse Stomach, Duyen Nguyen

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The Role of Pro-Longevity MicroRNAs in Aging, Sarah Noureddine

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Deciphering the Role and Clinical Application of the FGFR4-KLB-FGF19 Axis in Colorectal Neoplastic Progression, Michael Rohr

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BMP-7 Ameliorates Ponatinib Induced Muscle Cell toxicity: An in vitro and in vivo Study, Ayushi Srivastava

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Virus Mediated Delivery of Signals to Enhance NK Cell Mediated Killing of Tumor Cells, Namita Varudkar

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Computational Strain Analysis in Microbiome Datasets with Application to Skin Disease, Minerva Fatimae Ventolero

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Intrahost Diversity of Staphylococcus aureus in Carriage among Native Americans, Julia Webb

Theses/Dissertations from 2021

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Downregulation of miR-34a via Calorie Restriction Regulates Lipid Metabolism in the Liver of Long-living Ames Dwarf Mice, Sarah Ashiqueali

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Investigating the Role of the Skeletal Muscle in Amyotrophic Lateral Sclerosis Neuromuscular Junction Dysfunction, Agnes Badu-Mensah

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Chitosan-Gallium Nanocomposite: Synthesis, Characterization and Antibacterial Activity, Samjhana Bhandari

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Modulation of Fat Taste by Diet and Hormones, Ashley Calder

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Regulation of Actin Assembly, Mechanics, and Structure by Intracellular Environmental Factors, Nicholas Castaneda

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Sex Differences in Peripheral Fat Detection and Metabolism, Naima Dahir

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Doxorubicin-Induced Differential Patterns of Cell Death in the Skeletal Muscle, Fatima Bianca Dessouki

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Reassessing the Transcriptional Regulation of Protective CD4 T Cell Responses Against Influenza A Virus, Kunal Dhume

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Development of Adjunctive Agents for Difluoromethylornithine Anti-cancer Therapy, Aiste Dobrovolskaite

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Anti-MAP Triple Therapy Supports Immunomodulatory Therapeutic Response in Crohn's Disease Through Downregulation of NF-kB Activation in the Absence of MAP Detection, Erij Elkamel

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Transcriptomic Analyses Reveal Distinct Responses of Differentiated and Poorly-differentiated Intestinal Epithelial Cells to Lipid Peroxides, Nisreen Faizo

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The Consequence of Loss of Expression of AR-targeting MicroRNAs in Prostate Cancer Progression, Kavya Ganapathy

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Chaperonin-containing TCP1 Complex (CCT) Promotes Breast Cancer Uncontrolled Growth, Heba Ghozlan

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Novel Mechanisms Underlying Drug-resistant Metastasis and Relapse in Breast Cancer, Jie Hao

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Influence of Geography on the Healthy Gut Microbiome and the Role of the Gut Microbiome in IBD Symptom and Disease Progression, Sayf Al-Deen Hassouneh

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Investigating Effects of Ribosomal Occupancy on the Production of the Clamp Loader Subunits Tau and Gamma, Akhmetzada Kargazhanov

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Effects of Endogenous E. coli Molecules on Translational Fidelity, Piotr Lagod

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Bacterial Association Networks from Healthy and Cancer-associated Gut Microbiomes, Mark Loftus

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Utilization of HBPE Nanoparticles for Optimizing Drug Delivery to Cancer Cells, Daniel Nierenberg

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Characterization of a Cell Migration Defect in Drosophila melanogaster Border Cells in Response to the Chlamydia trachomatis TepP Effector, Kayli Rohal

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Competence Transcriptome Changes in Streptococcus Pneumoniae, Smitha Shambhu

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Spermidine Rescued PTPN2/22 Function in CRISPR-Cas9-edited T-cells with PTPN2/22 SNPs Linked to Crohn's Disease and Rheumatoid Arthritis, Ameera Shaw

Theses/Dissertations from 2020

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Monitoring Pathological Gene Expression and Studying Endogenous Epigenetic Architecture by CRISPR/Cas9-based Tool Development using alpha-Synuclein as a Model, Levi Adams

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Optimization of Cryopreserved Memory CD4 T Cell Mediated Protection against Lethal Influenza A Virus Infection in Mice, Fahmida Alam

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The Role of Nicotine in Exacerbating The Inflammatory Response in Macrophages Infected with Mycobacterium avium paratuberculosis in Crohn's Disease Smokers, Dania Alqasrawi

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Copper/N-acetylcysteine Coated Iron Oxide Nanoparticles Synthesis, Characterization, and Antimicrobial Activities, Danya Belnour

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HIV Infection in Women: Novel Approaches for Prevention, Michelle Cherne

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Early Host Defense Mechanisms against La Crosse Virus Infection, Maria A. Cruz Zamora

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Single Cell Forensic Genomics - DNA Profiling of Micromanipulated Single Spermatozoa, Haley Hardin

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Gelsolin-Mediated Actin Filament Severing in Crowded Environments, James Heidings

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The Role of Notch1, IL-6 and miR-146a in Inflammation and Infection in Crohn's Disease Non-Responders to Anti-TNF-Alpha Therapy, Esra'a Keewan

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Mapping of the Rat Intrinsic Cardiac Nervous System in 3D Reconstructed Hearts, Clara Leung

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The Innate Immune Response to House Dust Mite in Allergic Airway Inflammation, Madelyn Miller

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Identification of Novel Antimalarials From Natural Product Inspired Libraries, David Perry

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Novel Roles of RIP2 in Inflammation and Resolution, Michael Shehat

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Chaperonin-containing TCP-1 Modulates Breast Cancer Growth and Malignancy, Anne Showalter

Theses/Dissertations from 2019

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AB Toxins: Recovery from Intoxication and Relative Potencies, Patrick Cherubin

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Alpha-Tocopherol Reduces VLDL Secretion Through Modulation of the VLDL Transport Vesicle, Ryan Clay