Abstract
A new in vitro culture model for latency of tuberculosis pathogen suitable for screening chemical libraries was developed by subjecting the pathogen to multiple stresses that the pathogen is thought to encounter in the host. When subjected to these stress factors, the pathogen develops key features characteristic of latency, drug resistance and lipid storage. Using the culture, a method to screen chemicals was developed. This method is suitable for high through put screening.
Document Type
Patent
Patent Number
US 8,211,446
Application Serial Number
12/870,952
Issue Date
7-3-2012
Current Assignee
UCFRF
Assignee at Issuance
UCFRF
College
Burnett School of Biomedical Sciences
Department
Biomolecular Science Center
Allowance Date
3-1-2012
Filing Date
8-30-2010
Assignee at Filing
UCFRF
Filing Type
Nonprovisional Application Record
Donated
no
Recommended Citation
Kolattukudy, Pappachan; Daniel, Jaiyanth; Deb, Chirajyoti; and Sirakova, Tatiana, "In vitro model of latent mycobacterial infection (DIV II)" (2012). UCF Patents. 265.
https://stars.library.ucf.edu/patents/265