Abstract

All cells require polyamines in order to grow. Many cell types (including cancer cells) have active polyamine transporters which import extracellular polyamines into the cell. Our invention is the development of new lipophilic polyamines which can access cells via their polyamine transport system. The long lipid tails facilitate the formation of assembled complexes which are recognized and imported into cells. The invention describes several examples of using this technology for drug delivery and includes: a) the efficient delivery of foreign DNA into Chinese hamster ovary cells and expression of the protein encoded by the foreign DNA; and b) the delivery of saporin (a plant toxin which blocks protein synthesis). The invention is novel because it uses the polyamine transport system to selectively target cells with active polyamine transport systems. Since cancer cells have active polyamine transporters, it is possible to deliver corrective genes and/or toxins selectively to these cell

Document Type

Patent

Patent Number

US 7,910,363

Application Serial Number

12/113,970

Issue Date

3-22-2011

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

College of Sciences

Department

Chemistry

Allowance Date

12-6-2010

Filing Date

5-2-2008

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

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