Abstract

methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqeous redox catalyst with enhanced activity at an acidic to moderaly alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decompostion, decontamination and inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fuorescent probe in immunoassays or other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of the nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices. Versatility and uses of the nanoceria compositions are controlled by pH value, choice of dye substrate and thickness of the polymer coating on the ceria nanoparticles.

Document Type

Patent

Patent Number

US 8,883,519

Application Serial Number

12/704,678

Issue Date

11-11-2014

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

NanoScience Technology Center

Department

NanoScience Technology Center

Allowance Date

7-11-2014

Filing Date

2-12-2010

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

Download Patent

Share

COinS