Title

Design considerations for surface plasmon resonance-based fiber-optic detection of human blood group

Authors

Authors

A. K. Sharma; R. Jha; H. S. Pattanaik;G. J. Mohr

Comments

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Abbreviated Journal Title

J. Biomed. Opt.

Keywords

blood-group sensor; plasmon; optical fiber; sensitivity; SENSOR; SPECTROSCOPY; SENSITIVITY; Biochemical Research Methods; Optics; Radiology, Nuclear Medicine &; Medical Imaging

Abstract

A fiber-optic surface plasmon resonance (SPR) sensor for the detection of human blood groups is proposed. Previous experimental results describing the wavelength-dependent refractive index variation of multiple samples of different blood groups are considered for theoretical calculations. The spectral interrogation method, along with silica fiber and silver layer, is considered. The sensor's performance is closely analyzed in terms of shift in SPR wavelength and SPR curve width in order to optimize the design parameters for a reliable and accurate blood-group identifier. The sensor design parameters include silver layer thickness, fiber core diameter, sensing region length, and temperature variation. The results are explained in terms of light coupling and plasmon resonance condition. The proposed sensing probe is able to provide high sensitivity and accuracy of blood-group detection, thereby opening an easy and reliable window for medical applications. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3275476]

Journal Title

Journal of Biomedical Optics

Volume

14

Issue/Number

6

Publication Date

1-1-2009

Document Type

Article

Language

English

First Page

6

WOS Identifier

WOS:000274267900048

ISSN

1083-3668

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