Title

Helicobacter pylori Infection and Light Chain Gammopathy

Authors

Authors

J. A. Giron;S. L. Shah

Comments

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Abbreviated Journal Title

Clin. Dev. Immunol.

Keywords

RUSSELL BODY GASTRITIS; TUMOR-SUPPRESSOR; HUMAN-DISEASE; CAGA; UREASE; VACA; Immunology

Abstract

Objective. Helicobacter pylori provokes a host of immune alterations upon colonizing the gastric mucosa. Design. We report 22 individuals with confirmed Helicobacter pylori infection who were also managed for the concurrent elevation of immunoglobulin free light chain (kappa and lambda) levels. Result. Of the 22 patients, 15 patients (68.2%) had elevated free light chain levels: 6 patients (40%) had only kappa chain elevation, 2 patients (13.3%) had only lambda chain elevation, and 7 patients (46.7%) had both kappa and lambda chain elevation. Twenty out of the 22 patients (90.9%) were microbiologically confirmed cured with 3 patients being lost to follow-up for repeat levels. Of the 3 patients who were lost to follow-up, 1 patient had only kappa chain elevation, 1 patient had only lambda chain elevation, and 1 patient had both kappa and lambda chain elevation. For those who were cured (19 patients), 5 patients with kappa elevation had normalized values, 4 patients with lambda elevation had normalized values, and 2 patients with combined kappa and lambda elevation had normalized values. For 6 out of the 19 patients, the light chain levels remained elevated. Conclusion. We speculate that the Helicobacter pylori infection disrupts the immunoglobulin system with potential implications being discussed below.

Journal Title

Clinical & Developmental Immunology

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

7

WOS Identifier

WOS:000328401400001

ISSN

1740-2522

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