Title

Immunomodulation and T Helper TH1/TH2 Response Polarization by CeO2 and TiO2 Nanoparticles

Authors

Authors

B. C. Schanen; S. Das; C. M. Reilly; W. L. Warren; W. T. Self; S. Seal;D. R. Drake

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

PLoS One

Keywords

CERIUM OXIDE NANOPARTICLES; DENDRITIC CELL MATURATION; ANTIGEN-PRESENTING CELLS; BLOOD MONONUCLEAR-CELLS; TH1 IMMUNE-RESPONSES; TITANIUM-DIOXIDE; REACTIVE OXYGEN; IN-VITRO; IMMUNOLOGICAL MODEL; CYTOKINE RELEASE; Multidisciplinary Sciences

Abstract

Immunomodulation by nanoparticles, especially as related to the biochemical properties of these unique materials, has scarcely been explored. In an in vitro model of human immunity, we demonstrate two catalytic nanoparticles, TiO2 (oxidant) and CeO2 (antioxidant), have nearly opposite effects on human dendritic cells and T helper (T-H) cells. For example, whereas TiO2 nanoparticles potentiated DC maturation that led towards T(H)1-biased responses, treatment with antioxidant CeO2 nanoparticles induced APCs to secrete the anti-inflammatory cytokine, IL-10, and induce a T(H)2-dominated T cell profile. In subsequent studies, we demonstrate these results are likely explained by the disparate capacities of the nanoparticles to modulate ROS, since TiO2, but not CeO2 NPs, induced inflammatory responses through an ROS/inflammasome/IL-1 beta pathway. This novel capacity of metallic NPs to regulate innate and adaptive immunity in profoundly different directions via their ability to modulate dendritic cell function has strong implications for human health since unintentional exposure to these materials is common in modern societies.

Journal Title

Plos One

Volume

8

Issue/Number

5

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

12

WOS Identifier

WOS:000319055600046

ISSN

1932-6203

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