A new in vitro culture model for latency of tuberculosis pathogen suitable for screening chemical libraries was developed by subjecting the pathogen to multiple stresses that the pathogen is thought to encounter in the host. When subjected to these stress factors, the pathogen develops key features characteristic of latency, drug resistance and lipid storage. Using the culture, a method to screen chemicals was developed. This method is suitable for high through put screening.
US 8,551,499 B2
Application Serial Number
Assignee at Issuance
Burnett School of Biomedical Sciences
Biomolecular Science Center
Assignee at Filing
Nonprovisional Application Record
Kolattukudy, Pappachan; Daniel, Jaiyanth; Deb, Chirajyoti; and Sirakova, Tatiana, "In vitro model of latent mycobacterial infection" (2013). UCF Patents. 720.