Prior to the settlement of Charles Town in 1670, the Spanish, through the mission reductions, dominated many of the southeastern Indian tribes. Although the mission Indians generally accepted the discipline imposed, several revolts against Spanish rule nevertheless occurred, the suppression of which doubtless produced many malcontents. Furthermore the Spanish regarded the English settlement of Carolina as an encroachment on Spanish territory, although evidently not unwelcome by Indians who had become hostile to the Spaniards.
Boyd, Mark F.
"Diego Pena’s Expedition to Apalachee and Apalachicolo in 1716,"
Florida Historical Quarterly: Vol. 28
, Article 4.
Available at: https://stars.library.ucf.edu/fhq/vol28/iss1/4