High Impact Practices Student Showcase Spring 2025

Cytarabine in children with Acute Promyelocytic Leukemia
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Course Code
HSC
Course Number
4930
Faculty/Instructor
Professor Steven Burroughs
Faculty/Instructor Email
Steven.Burroughs@ucf.edu
Abstract, Summary, or Creative Statement
Leukemia is a form of blood cancer, originating in the bone marrow, and
accounts for over 30% of all cancer diagnoses in children. While there are
many forms of treatment which may be used to treat Leukemia,
chemotherapy is the most common and most effective form. The “gold
standard” treatment for pediatric Leukemia, specifically Acute Promyelocytic
Leukemia, is Daunorubicin (DNR). Another chemotherapy drug, which is
used only in combination with DNR, is Cytarabine (Ara-C). Due to the
aggressive nature of treatment, there are a number of side effects.
This clinical trial seeks to determine the non-inferiority of
DNR alone, as the addition of Ara-C significantly increases the risk for
severe side effects.As a result of the intensive research we have learned to
differentiate between different types of research, understand how to
read and gather information from clinical trials, and perform
comparative analyses of clinical trials in addition to gaining a
comprehensive knowledge on Leukemia itself.
Additionally, we have developed a
heightened awareness of identifying potential biases in research which
may alter the delivery of certain results. We have gained a thorough
understanding of the ethical principles behind different treatment protocols
which has absolutely prepared us to be better clinicians.
Together, we have identified significant room for improvement on the
current status of global standards of care, and we seek to be more critical
consumers of research in the future. We certainly see the impact potential of
what we have learned far beyond the scope of the classroom.
Keywords
Leukemia;pediatric;Cytarabine;chemo;Ara-C;health;side effects;study
Recommended Citation
Kovacevic, Bojana; Brandt, Erika; and Albrecht, Kaylee, "Cytarabine in children with Acute Promyelocytic Leukemia" (2025). High Impact Practices Student Showcase Spring 2025. 37.
https://stars.library.ucf.edu/hip-2025spring/37
