High Impact Practices Student Showcase Spring 2025

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Course Code

HSC

Course Number

4930

Faculty/Instructor

Professor Steven Burroughs

Faculty/Instructor Email

Steven.Burroughs@ucf.edu

About the Author


This project was authored by Linda Canales, Caitlyn Kelly, and Lillian Nguyen, seniors majoring in Health Sciences. We would like to express our sincere gratitude to Professor Burroughs for his invaluable guidance and consistent support throughout the project. His feedback and direction were instrumental in refining our approach and enhancing our understanding of the clinical trial process.

We also wish to acknowledge the clinical teams behind the Cequa™ (Cyclosporine 0.09%) trials for providing essential research data. Their work in addressing Dry Eye Disease has significantly contributed to both our project and the broader field of ophthalmology. Additionally, we are thankful to the trial participants for their dedication, which has played a crucial role in advancing patient care and research in this area.

Abstract, Summary, or Creative Statement

This project evaluated the clinical efficacy of Cequa™ (Cyclosporine 0.09%) in individuals with Dry Eye Disease (DED) who showed minimal improvement with lower-dose cyclosporine (0.05%). The study explored real-world pharmaceutical applications, focusing on clinical trial design, patient-centered outcomes, and treatment limitations. A review of peer-reviewed literature demonstrated that Cequa 0.09% produced statistically significant improvements in both corneal health and symptom reduction when compared to Restasis® and Lifitegrast (Xiidra®).

The project was developed within the framework of a Health Sciences Seminar course and adhered to a structured timeline with instructor feedback. Emphasis was placed on scientific analysis, effective communication, and teamwork. Additionally, the project examined the importance of diversity in clinical trials and proposed strategies for more inclusive study designs in the future.

By bridging academic concepts with practical clinical research, this project contributed to a deeper understanding of how treatments move from research into real-world patient care. It highlights the value of evidence-based solutions and the importance of making therapies accessible and effective for diverse patient populations.

Keywords

Dry Eye Disease, Cyclosporine 0.09% (Cequa™), Ophthalmology, Clinical Trials, Patient-Centered Research, Integrative Learning Experience

Effect of Cequa™ in Subjects With Dry Eye Disease


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