High Impact Practices Student Showcase Spring 2025
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Course Code
PCB
Course Number
4943
Faculty/Instructor
Professor Nicole Verity
Faculty/Instructor Email
Nicole.Verity@ucf.edu
Abstract, Summary, or Creative Statement
Lung cancer is the deadliest and second most prevalent cancer in the United States, with approximately 230,000 new cases and 125,000 deaths reported yearly, according to the American Cancer Society. Annually, more people die of lung cancer than of colon, breast, and prostate cancers combined. Recent research has shown that GABA and dopamine independently induce apoptosis in lung cancer cells. Parameters such as LD50 and IC50 are essential to determine optimal concentration for human toxicity and CI analysis can be utilized to understand the synergistic interactions between two agents. In this research project, the relative effectiveness of GABA and dopamine dual therapy on lung cancer cells to induce apoptosis is examined using these parameters to evaluate whether a relationship between these two reagents can be established. Using quantitative cell counting and qualitative immunofluorescence microscopy, the optimal concentrations at which each reagent induces apoptosis can be identified. In the future, this knowledge can be used to develop more effective management strategies for lung cancer and ultimately further investigation into innovative therapies for NSCLC treatment.
Keywords
Lung cancer; cancer; A549; lung adenocarcinoma; NSCLC; non-small cell lung cancer; GABA; Dopamine; therapy; dual therapy; treatment
Recommended Citation
Abdalla, Ahmed and Olajide, Jemimah, "GABA and Dopamine Dual Therapy: A Potential Treatment for A549 Non-Small Cell Lung Cancer" (2025). High Impact Practices Student Showcase Spring 2025. 55.
https://stars.library.ucf.edu/hip-2025spring/55
