GABA and Dopamine Dual Therapy: A Potential Treatment for A549 Non-Small Cell Lung Cancer

Authors

Ahmed Abdalla, University of Central FloridaFollow
Jemimah Olajide, University of Central FloridaFollow

Files

Course Code

PCB

Course Number

4943

Faculty/Instructor

Professor Nicole Verity

Faculty/Instructor Email

Nicole.Verity@ucf.edu

About the Author

Hello! We are Ahmed Abdalla and Jemimah Olajide. We are both fourth year Biomedical Sciences undergraduate students pursuing future careers in medicine. We would like to express our sincere gratitude to Professor Verity for her mentorship and guidance throughout the course of this project so far. Her assistance in effectively and efficiently coordinating resources and providing valuable insights have been a tremendous help to our research. We would also like to extend our thanks to Dr. Borgon for providing us with the foundational skills and experience through the Quantitative Biological Methods class. Finally, we are appreciative of our support from the PILOT program for providing us with the opportunity to conduct this project.

Abstract, Summary, or Creative Statement

Lung cancer is the deadliest and second most prevalent cancer in the United States, with approximately 230,000 new cases and 125,000 deaths reported yearly, according to the American Cancer Society. Annually, more people die of lung cancer than of colon, breast, and prostate cancers combined. Recent research has shown that GABA and dopamine independently induce apoptosis in lung cancer cells. Parameters such as LD50 and IC50 are essential to determine optimal concentration for human toxicity and CI analysis can be utilized to understand the synergistic interactions between two agents. In this research project, the relative effectiveness of GABA and dopamine dual therapy on lung cancer cells to induce apoptosis is examined using these parameters to evaluate whether a relationship between these two reagents can be established. Using quantitative cell counting and qualitative immunofluorescence microscopy, the optimal concentrations at which each reagent induces apoptosis can be identified. In the future, this knowledge can be used to develop more effective management strategies for lung cancer and ultimately further investigation into innovative therapies for NSCLC treatment.

Keywords

Lung cancer; cancer; A549; lung adenocarcinoma; NSCLC; non-small cell lung cancer; GABA; Dopamine; therapy; dual therapy; treatment

Recommended Citation

Abdalla, Ahmed and Olajide, Jemimah, "GABA and Dopamine Dual Therapy: A Potential Treatment for A549 Non-Small Cell Lung Cancer" (2025). High Impact Practices Student Showcase Spring 2025. 55.
https://stars.library.ucf.edu/hip-2025spring/55