Radial elasticity of self-assembled lipid tubules
Abbreviated Journal Title
lipid tubules; atomic force microscopy; finite element analysis; nanomechanics; MECHANICAL-PROPERTIES; CONTROLLED-RELEASE; PEPTIDE NANOTUBES; MICROSTRUCTURES; MICROTUBULES; FABRICATION; VIRUS; NANOPARTICLES; TEMPLATES; CYLINDERS; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &; Nanotechnology; Materials Science, Multidisciplinary
Self-assembled lipid tubules with crystalline bilayer walls represent useful supramolecular architectures which hold promise as vehicles for the controlled release of preloaded drugs and templates for the synthesis of one-dimensional inorganic materials. We study the local elasticity of lipid tubules of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine by radial atomic force microscope indentation, coupled with finite element analysis. A reduced stiffness is found to extend a distance of similar to 600 nm from the ends of lipid tubules. The middle section of lipid tubules is homogeneous in terms of their radial elasticity with a Young's modulus of similar to 703 MPa. The inhomogeneous radial elasticity likely arises from the variation of lipid packing density near the tubule ends.
"Radial elasticity of self-assembled lipid tubules" (2008). Faculty Bibliography 2000s. 1214.