Radial elasticity of self-assembled lipid tubules

    Authors

    Y. Zhao; K. Tamhane; X. J. Zhang; L. N. An;J. Y. Fang

    Comments

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    Abbreviated Journal Title

    ACS Nano

    Keywords

    lipid tubules; atomic force microscopy; finite element analysis; nanomechanics; MECHANICAL-PROPERTIES; CONTROLLED-RELEASE; PEPTIDE NANOTUBES; MICROSTRUCTURES; MICROTUBULES; FABRICATION; VIRUS; NANOPARTICLES; TEMPLATES; CYLINDERS; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &; Nanotechnology; Materials Science, Multidisciplinary

    Abstract

    Self-assembled lipid tubules with crystalline bilayer walls represent useful supramolecular architectures which hold promise as vehicles for the controlled release of preloaded drugs and templates for the synthesis of one-dimensional inorganic materials. We study the local elasticity of lipid tubules of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine by radial atomic force microscope indentation, coupled with finite element analysis. A reduced stiffness is found to extend a distance of similar to 600 nm from the ends of lipid tubules. The middle section of lipid tubules is homogeneous in terms of their radial elasticity with a Young's modulus of similar to 703 MPa. The inhomogeneous radial elasticity likely arises from the variation of lipid packing density near the tubule ends.

    Journal Title

    Acs Nano

    Volume

    2

    Issue/Number

    7

    Publication Date

    1-1-2008

    Document Type

    Article

    Language

    English

    First Page

    1466

    Last Page

    1472

    WOS Identifier

    WOS:000257861900023

    ISSN

    1936-0851

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