Title

Quantum Dot-Based OFF/ON Probe for Detection of Glutathione

Authors

Authors

S. Banerjee; S. Kar; J. M. Perez;S. Santra

Comments

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Abbreviated Journal Title

J. Phys. Chem. C

Keywords

IN-VIVO; SOLVOTHERMAL PROCESS; SELECTIVE DETECTION; ELLMANS REAGENT; SOLAR-CELLS; CDS; FLUORESCENT; NANORODS; PHOTOLUMINESCENCE; QUANTIFICATION; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, ; Multidisciplinary

Abstract

A simple strategy for detection of glutathione (GSH) in physiologically relevant concentrations is reported by manipulating the electron transfer pathways of surface-modified quantum dots. The probe consisted of fluorescent CdS:Mn/ZnS core/shell quantum dots (Qdot) properly conjugated to dopamine through CS(2)-assisted zero-length covalent coupling. Qdots exhibited bright yellow-orange emission at similar to 592 nm, which could be attributed to the (4)T(1) --> (6)A(1) transition of Mn(2+) ions in Qdot core. The fluorescently dark Qdots (OFF state) was obtained by modifying the Qdot surface with an electron rich dopamine molecule. The fluorescence of the probe was restored (ON state) when the disulfide bond was cleaved by the reducing GSH.

Journal Title

Journal of Physical Chemistry C

Volume

113

Issue/Number

22

Publication Date

1-1-2009

Document Type

Article

Language

English

First Page

9659

Last Page

9663

WOS Identifier

WOS:000266447600036

ISSN

1932-7447

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