Title

Cell therapy in the heart

Authors

Authors

L. S. Abdelli; H. Merino; C. M. Rocher;D. K. Singla

Comments

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Abbreviated Journal Title

Can. J. Physiol. Pharmacol.

Keywords

cardiomyopathy; cardiac myocytes; adult and embryonic stem cells; cell; transplantation therapy; clinical trials; ACUTE MYOCARDIAL-INFARCTION; PLURIPOTENT STEM-CELLS; BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; IMPROVE CARDIAC-FUNCTION; ADIPOSE-TISSUE; ISCHEMIC-HEART; MYOBLAST TRANSPLANTATION; REGENERATION ENHANCEMENT; SKELETAL MYOBLASTS; Pharmacology & Pharmacy; Physiology

Abstract

Cell therapy is emerging as a new strategy to circumvent the adverse effects of heart disease. Many experimental and clinical studies investigating the transplantation of cells into the injured myocardium have yielded promising results. Moreover, data from these reports show that transplanted stem cells can engraft within the myocardium, differentiate into major cardiac cell types, and improve cardiac function. However, results from clinical trials show conflicting results. These trials demonstrate significant improvements in cardiac function for up to 6 months. However, these improved functions were diminished when examined at 18 months. In this review, we will discuss the current literature available on cell transplantation, covering studies ranging from animal models to clinical trials.

Journal Title

Canadian Journal of Physiology and Pharmacology

Volume

90

Issue/Number

3

Publication Date

1-1-2012

Document Type

Review

Language

English

First Page

307

Last Page

315

WOS Identifier

WOS:000301431400005

ISSN

0008-4212

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